Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline

This article is protected by copyright. All rights reserved. The Lyme disease spirochete, Borrelia burgdorferi, can evade the host immune system by a process known as antigenic variation. The spirochete continually changes the sequence of a major surface protein, vlsE, to escape antibodies that would eliminate it. In this study we use next generation sequencing and novel software to study the DNA rearrangements that drive antigenic variability.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research