Profile of mutations in the reverse transcriptase and overlapping surface genes of hepatitis B virus in treatment-na ïve Indonesian HBV carriers.

Profile of mutations in the reverse transcriptase and overlapping surface genes of hepatitis B virus in treatment-naïve Indonesian HBV carriers. Jpn J Infect Dis. 2017 Oct 31;: Authors: Yamani LN, Yano Y, Utsumi T, Wasityastuti W, Rinonce HT, Widasari DI, Juniastuti, Lusida MI, Soetjipto, Hayashi Y Abstract Mutations in the reverse transcriptase (RT) region of the hepatitis B virus (HBV) genome are an important factor in reduced therapeutic effectiveness. However, the prevalence of these mutations in HBV strains isolated previously from Indonesia has not been systematically examined. Therefore, this study investigated the profile of mutations in the RT region and the associations of these mutations with amino acid changes in the surface protein in treatment-naïve Indonesian HBV carriers. Overall, 96 sequences of the full-length Indonesian HBV genome (genotype B, n=54; genotype C, n=42) were retrieved from the National Center for Biotechnology Information. Naturally occurring primary and/or compensatory drug resistance mutations were found in 6/54 (11.1%) genotype B strains and in 1/42 (2.4%) genotype C strains. The potential resistance against nucleos(t)ide analog and/or pretreatment mutations were more frequent in both genotypes but, the genotype C was much more than genotype B. The A-B interdomain region in the RT gene was more frequently mutated in genotype C than in genotype B (3.51±2.53 vs 1.08±1.52, P
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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