The association between NFKBIA polymorphisms and the progression of chronic hepatitis B virus infection among the Chinese Han population.

The association between NFKBIA polymorphisms and the progression of chronic hepatitis B virus infection among the Chinese Han population. Jpn J Infect Dis. 2017 Oct 31;: Authors: Lin Y, Su C, Niu J, Guo Z, Lu Y Abstract Based on the involvement of NFKIBA (NF-κB Inhibitor Alpha) in the NF-κB pathway, which is closely related with host immunity, and this present study aimed to determine if NFKIBA polymorphisms are associated with the disease progression of chronic hepatitis B virus (HBV) infection. Our study collected blood samples from a total of 212 treatment-naïve patients with chronic HBV infection were included in present study, and the blood samples were collected. NFKBIA polymorphisms were determined by using Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry. Enzyme-linked immunosorbent assays were employed to quantify the serum levels of TNF-α and IL-6. An unconditional logistic regression revealed that carriers of TT genotype at rs2233406 had a greater risk (OR=5.57, 95%CI=2.14-14.52) of chronic HBV infection progression. A similar association was observed for the rs2233409 polymorphism, in which the OR for the TT genotype was 4.06 (95%CI=1.70-9.71) when compared with the wildtype CC genotype. Mutations at rs2233406 and rs2233409 also impact liver function parameters and cytokine levels. However, null associations were between these parameters and polymorphism rs696. These finding suggest that t...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research