Predominance of serogroup 19 CC320/271 among penicillin-non-susceptible Streptococcus pneumoniae isolates after the introduction of the PCV7 vaccine in several regions of Japan.

Predominance of serogroup 19 CC320/271 among penicillin-non-susceptible Streptococcus pneumoniae isolates after the introduction of the PCV7 vaccine in several regions of Japan. Jpn J Infect Dis. 2017 Oct 31;: Authors: Oodate M, Kimura K, Banno H, Yokoyama S, Jin W, Wachino JI, Hasegawa Y, Arakawa Y Abstract Multidrug-resistant Streptococcus pneumoniae serogroup 19, including serotypes 19A and 19F, associated with clonal complex 320/271 (CC320/271), was previously shown to be predominant in many countries after the introduction of a seven-valent pneumococcal conjugate vaccine (PCV7). However, in Japan there has been no epidemiological research focused on penicillin-non-susceptible isolates after this event. Thus, we aimed to characterize penicillin-non-susceptible S. pneumoniae (PNSSP; penicillin minimum inhibitory concentration (MIC) ≥ 4.0 µg/ml) after the introduction of PCV7 in Japan. From throughout Japan, we collected 1057 pneumococcal isolates from 2010 to 2014. We then evaluated MICs and performed serotyping, multilocus sequence typing, and sequencing of penicillin binding protein (PBP) genes of 51 isolates (penicillin MIC ≥ 2.0 µg/ml). Twenty-three isolates (2.2%) showed penicillin-non-susceptibility (penicillin MIC ≥ 4.0 µg/ml). Serotypes 19F (14 isolates, 60.9%) and 23F (4 isolates, 17.4%), which are covered by the vaccine, were predominant among PNSSP strains. Only three isolates were of the non-vaccine serotype 19A....
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Source: Acta Microbiologica et Immunologica Hungarica - Category: Microbiology Authors: Tags: Acta Microbiol Immunol Hung Source Type: research
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Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
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Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Front Cell Infect Microbiol Source Type: research
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Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Nosocomial infections have become alarming with the increase of multidrug resistant bacterial strains of Acinetobacter baumannii. Being the causative agent in approximately 80% of the cases, these pathogenic gram-negative species could be deadly for hospitalized patients, especially in intensive care units utilizing ventilators, urinary catheters and nasogastric tubes. Primarily infecting an immuno-compromised system, they are resistant to most antibiotics and are the root cause of various types of opportunistic infections including but not limited to septicemia, endocarditis, meningitis, pneumonia, skin and wound sepsis a...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide. Antibiotic resistance profiles for S pneumoniae isolates identified from pediatric patients in mainland China remains to be established. The clinical features, antimicrobial resistance, and multidrug resistance patterns of S pneumoniae were retrospectively analyzed at 10 children's hospitals in mainland China in 2016. Among the collected 6132 S pneumoniae isolates, pneumococcal diseases mainly occurred in children younger than 5 years old (85.1%). The resistance rate of S pneumoniae to clindamycin, erythromycin, tetr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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