Obese Children May Have More Asthma Complications Obese Children May Have More Asthma Complications
Children with asthma who are also obese are admitted to the hospital more often for asthma complications, according to a recent study in Japan.Reuters Health Information
AbstractPurpose of ReviewMany of the diseases and dysfunctions described in the paradigm of the developmental origins of health and disease have been studied in relation to prenatal nutrition or environmental toxicant exposures. Here, we selectively review the current research on four exposures —two nutritional and two environmental—that have recently emerged as prenatal risk factors for long-term health outcomes.Recent FindingsRecent studies have provided strong evidence that prenatal exposure to (1) excessive intake of sugar-sweetened beverages, (2) unhealthy dietary patterns, (3) perfluoroalkyl substances, a...
ConclusionsIn a cohort of unselected consecutive patients with adult-onset asthma, 5.9% fulfilled criteria for severe asthma and 2% qualified for anti-IL-5 treatment. Both groups represent a high burden to healthcare and specifically targeted treatment could lead to lower use of healthcare at long-term.
CONCLUSION: Asthma is a disease that is often diagnosed in childhood but can present at any age. There is debate in the field as to whether asthma is one disease or several different diseases that include airway inflammation as a key finding. There are risk factors for disease in the environment and thru co-morbidities that likely play significant roles in both the origins of asthma, the development of symptoms, and the response to treatment. These factors are even more important as we look towards the future with the goal of personalized medicine. RESPONSE TO REVIEWERS: RESPONSE: We appreciate the thoughtful comments...
This article examines the roots of asthma across the ages including atopy, the role of the microbiome and viral infections, along with comorbidities/confounders such as obesity, aspirin-exacerbated respiratory disease (AERD), neutrophilic asthma, cigarette smoking and the possibility of an asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome.
Conclusions In a cohort of unselected consecutive patients with adult-onset asthma, 5.9% fulfilled criteria for severe asthma and 2% qualified for anti-IL-5 treatment. Both groups represent a high burden to healthcare and specifically targeted treatment could lead to lower use of healthcare at long-term.
Both obesity and high dietary fat intake activate the nucleotide oligomerization domain –like receptor protein 3 (NLRP3) inflammasome.
The NLRP3 inflammasome is upregulated in obese asthmatics and following a high saturated fat meal in non-obese asthmatics. Both reversal of obesity and restriction of dietary saturated fat intake warrant further exploration as anti-inflammatory strategies in asthma.
Conclusion: Comparisons between PAR and SAR showed that the conditions are differentially associated with current wheeze and BMI.Int Arch Allergy Immunol
Publication date: Available online 3 May 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Tianshi David Wu, Emily P. Brigham, Roger Peng, Kirsten Koehler, Cynthia Rand, Elizabeth C. Matsui, Gregory B. Diette, Nadia N. Hansel, Meredith C. McCormack
Publication date: May–June 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 3 Author(s): Sheniz Moonie, Mary Beth Hogan