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Obese Children May Have More Asthma Complications Obese Children May Have More Asthma Complications

Children with asthma who are also obese are admitted to the hospital more often for asthma complications, according to a recent study in Japan.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pediatrics News Source Type: news

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Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncontrolled asthma population. Secondary outcomes were to examine how these symptom profiles influence response to treatment. Twice-daily electronically recorded data from 1701 patients were examined in relation to the population demographics. Reliever treatment with salbutamol was then compared with extra-fine beclometasone/formoterol maintenance and reliever therapy (MART). Exacerbation frequency was t...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Immunoglobulin therapy plays a critical role in the treatment of immunodeficiency disorders as well as autoimmune and inflammatory conditions. In immunodeficient patients, there has been controversy whether in...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case Report Source Type: research
Background: Comorbidities postulated as a significant obstacle to get bronchial asthma (BA) controlled. Adults’ obesity is a recognized BA comorbidity, but pediatric data are fewer.Aim: To find obesity prevalence and its correlation with BA severity among inner city children in St-Petersburg, Russia.Methods: We search 2016 discharge database (4257 cases) of 2 in-patient pediatric allergy clinics. There were 991 patients with BA; this covers 35,23% of hospitalized pediatric asthma (2813 patients) and 5,67% of total registered BA in the city per year (17498 patients). We also analyzed 1096 outpatient cases in different...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Respiratory Epidemiology Source Type: research
Conclusion: Obesity has a negative impact on clinical presentation of asthma in children, but we could not find significant alteration in pulmonary functional tests linked with obesity.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Asthma and Allergy Source Type: research
Conclusion: The findings that a late high BMI increases the risk of asthma, together with a significant trend of increasing asthma prevalence among children with persistently high BMI, support a possible connection between overweight and asthma.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Asthma and Allergy Source Type: research
Conclusions: The established phenotype of SA for our population was allergic, non-obese children, with normal lung function and variable FeNO.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Asthma and Allergy Source Type: research
Background: Severe asthma is a complex amalgam of phenotypes and comorbidities. Most novel therapies target type 2 disease so determining the optimal treatment for each patient will likely require detailed phenotyping. The WSAC study recruited 491 participants split between severe asthma (n=342), mild asthma (n=69) and healthy controls (n=80) for detailed phenotyping; inclusion criteria were asthma diagnosed as per guidelines and at least 1 exacerbation in 12 months. Smokers and those with comorbidity were included in order to reflect clinical practice. We aimed to assess the differences in demographic and clinical charact...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusion: Our study has identified differential expressed proteins in PBMC and induced sputum in obese-asthma phenotype, which were associated with metabolic inflammatory pathways.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Dysbiosis of the gut microbiota has been associated with increasing numbers of diseases, including obesity, diabetes, inflammatory bowel disease, asthma, allergy, cancer and even neurologic or behavioral disorders. The other side of the coin is that a healthy microbiota leads to a healthy human development, to a mature and well trained immune system and to an efficient metabolic machinery. What we have learned in adults is in the end the result of a good start, a programmed, healthy development of the microbiota that must occur in the early years of life, probably even starting during the fetal stage.
Source: Archives of Medical Research - Category: Research Authors: Tags: Reviewer Article Source Type: research
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Source: Allergy - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
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