Biological Cleavage of the C –P Bond in Perfluoroalkyl Phosphinic Acids in Male Sprague-Dawley Rats and the Formation of Persistent and Reactive Metabolites

Conclusions:
PFPiAs were metabolized in Sprague-Dawley rats to form persistent PFPAs as well as 1H-PFAs, which contain a labile hydrogen that may undergo further metabolism. These results in rats produced preliminary findings of the pharmacokinetics and metabolism of PFPiAs, which should be further investigated in humans. If there is a parallel between the disposition of these chemicals in humans and rats, then humans with detectable amounts of PFPiAs in their blood may be undergoing continuous exposure. https://doi.org/10.1289/EHP1841

Received: 1 March 2017
Revised: 20 September 2017
Accepted: 21 September 2017
Published: 3 November 2017

Address correspondence to S. Joudan, Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON M5S 3H6 Canada. Telephone: [phone]. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP1841).
The authors declare they have no actual or potential competing financial interests.
†Current address: Man-Technology-Environment (MTM) Research Centre, Örebro University, Örebro, Sweden.
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Source: EHP Research - November 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research