Biological Cleavage of the C –P Bond in Perfluoroalkyl Phosphinic Acids in Male Sprague-Dawley Rats and the Formation of Persistent and Reactive Metabolites

Conclusions: PFPiAs were metabolized in Sprague-Dawley rats to form persistent PFPAs as well as 1H-PFAs, which contain a labile hydrogen that may undergo further metabolism. These results in rats produced preliminary findings of the pharmacokinetics and metabolism of PFPiAs, which should be further investigated in humans. If there is a parallel between the disposition of these chemicals in humans and rats, then humans with detectable amounts of PFPiAs in their blood may be undergoing continuous exposure. https://doi.org/10.1289/EHP1841 Received: 1 March 2017 Revised: 20 September 2017 Accepted: 21 September 2017 Published: 3 November 2017 Address correspondence to S. Joudan, Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON M5S 3H6 Canada. Telephone: (416) 946-7736. Email: shira.joudan@mail.utoronto.ca Supplemental Material is available online (https://doi.org/10.1289/EHP1841). The authors declare they have no actual or potential competing financial interests. †Current address: Man-Technology-Environment (MTM) Research Centre, Örebro University, Örebro, Sweden. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Abstract Two-step targeted 2D planar chromatographic method (2DTLC) was used in the determination of ginkgolic acids in pharmaceuticals and dietary supplements. The choice of the extraction method and the separation technique was guided by the formulation type (capsule, tablet, tincture) with expected low amounts of ginkgolic acids in the analyzed herbal samples. Separation of ginkgolic acids C15:1 and C17:1 on HPTLC RP18 WF254s was preceded by its separation from the sample matrix on TLC Si60 F254s. Mobile phases consisted of acetonitrile/water/formic acid (80:20:1, V/V/V) and n-heptane/ethyl acetate/formic acid ...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Authors: Yoon D, Jang JH, Choi BJ, Kim TY, Han CH Abstract Biosignals like electrocardiogram or photoplethysmogram have been widely used for monitoring and determining status of patients. However, it has been recently discovered that more information than that we have used traditionally were included in the biosignals after artificial intelligence (AI) was applied. Most meaningful advancement of current AI was in deep learning. The deep learning-based models show the best performance in most area in current due to the distinguished characteristic that it is able to extract important features from raw data. For that...
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
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Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
CONCLUSIONS: Patients with morbid obesity need health, nutritional, and psychological education. PMID: 31955190 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Jahołkowski P, Niewiadomska J, Wciórka J, Kowalski M, Świtaj P Abstract Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated. Clozapine-induced myocarditis (CIM) is a relatively rare but potentially life-threatening complication of clozapine therapy; however, the underlying mechanism has not been so far well elucidated. Factors predisposing to CIM include a rapid dose titration, advanced age and co-administration of sodium valproate. In this paper, we present a case of a 22-year-old male patient with refrac...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
In this study, we examined bacterial communities from cyanobacterial-lichen and moss crust soils in five desert habitats in northern China, and evaluated the relative importance of environmental factors and biocrust development versus geographic distance to the distance–decay relationship. To explore the effects of the sampling scale on geographical patterns, we also examined soil bacterial communities along the slope of sand dunes. Across the five desert habitats, bacterial α-diversity, phylogenetic diversity, and the dominant bacterial phyla in cyanobacterial-lichen crusts did not increase consistently with p...
Source: Soil Biology and Biochemistry - Category: Biology Source Type: research
In this study, benzyl benzoate was successfully synthesized via enzymatic acylation using three immobilized enzymes as biocatalysts. Different acyl donors (benzoic acid and benzoic anhydride), operation regimes (batch, fed-batch), mixing modes (conventional mechanical stirring and ultrasound), process parameters (temperature, substrate molar ratio of acyl donor to acyl acceptor), presence or absence of solvents, enzyme amount and type were evaluated. Benzoic acid is a solid that is difficult to solubilize and, thus, was not efficient as acyl donor for the synthesis of benzyl benzoate. On the other hand, benzoic anhydride w...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ06081B, PaperJun Kang Guo, Yanping Li , Xinhao Ren, Huihui Xu, Ting Wei, Honglei Jia, Li Hua, Yi Zhang, Yongtao Li A hydrophobic functional ionic liquid (IL) [N4444]AOT based on sodium bis(2-ethylhexyl)sulfosuccinate anion was designed and synthesized for cadmium extraction. To study the characteristics of [N4444]AOT, fourier transform infrared (FTIR) spectroscopy,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09132G, CommunicationJun Zhou, Ling Zhou, Lishan Yang, Tao Chen, Jiaqi Li, Hao Pan, Ya Hui Yang, Zhongchang Wang We design a carbon-free Si/polyaniline hybrid anode composed of porous Si dendrites and oxalic acid doped polyaniline coatings. Such a 3D conductive porous structure offers feasibility to facilitate the transport... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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