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TYRP1 mRNA goes fishing for miRNAs in melanoma

Nature Cell Biology 19, 1311 (2017). doi:10.1038/ncb3637 Authors: Maria S. Soengas &Eva Hernando A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research

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Accuracy of Skin Cancer Diagnosis by Physician Assistants Compared With Dermatologists Randomly saw this article, and figured I'd post it here. Research on primary care (methodological objections aside) consistently shows that midlevels provide similar outcomes to physicians, enabling independent practice in an increasing number of States. I've gotten worried that that trend would extend to other medical... Compared with dermatologists, physician assistants have lower diagnostic accuracy for melanoma.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
FRIDAY, April 20, 2018 -- Physician assistants (PAs) perform more skin biopsies per case of skin cancer diagnosed and diagnose fewer melanomas in situ than dermatologists, according to a study published online April 18 in JAMA Dermatology. Alyce M....
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Schorch B, Heni H, Zahaf NI, Brummer T, Mione M, Schmidt G, Papatheodorou P, Aktories K Abstract Clostridium perfringens toxin TpeL belongs to the family of large clostridial glycosylating toxins. The toxin causes N-acetylglucosaminylation of Ras proteins at threonine35 thereby inactivating the small GTPases. Here, we show that all main types of oncogenic Ras proteins (H-Ras, K-Ras and N-Ras) are modified by the toxin in vitro and in vivo. Toxin-catalyzed modification of Ras was accompanied by inhibition of the MAP kinase pathway. Importantly, TpeL inhibited the paradoxical activation of the MAP kinase pat...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Superficial radiation therapy device developer Sensus Healthcare (NSDQ:SRTSU) today released plans for a global expansion, including new distribution agreements in China, Germany, Mexico, Cuba and Costa Rica. Sensus makes low-energy photon X-ray systems for treating non-melanoma skin cancers, including basal cell and squamous cell carcinomas, and keloids. The Boca Raton, Fla.-based company refers to the technology as superficial radiation therapy, and claims that the tech has been sued to “effectively and safely treat oncological and non-oncological skin conditions.” “Following our new partnersh...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Distribution Oncology Sensus Healthcare LLC Source Type: news
(MedPage Today) -- News, features, and commentary about cancer-related issues
Source: MedPage Today Public Health - Category: American Health Source Type: news
Atopic dermatitis (AD), a chronic inflammatory skin disease, affects between 2-10% of the adult population in industrialized nations. AD is primarily treated with topical emollients and anti-inflammatory agents such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI), though more severe cases require systemic immunosuppressive agents. TCIs currently carry a black box warning label for a possible association with cutaneous malignancy, including melanoma and keratinocyte carcinomas (KCs), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Incidence of nonmelanoma skin cancer (NMSC) exceeds all other types of cancer combined. Cumulative and intermittent sun exposure are known risk factors for the development of NMSC. Since obesity has been shown to contribute to cancer incidence, we hypothesized that heavier individuals (BMI> 25 kg/m2) have increased the risk of NMSC when accounting for sun exposure. Using the Womens Health Initiative (WHI) cohort, we investigated the risk of NMSC with sun exposure and anthropometric measures. We analyzed the incidence of NMSC associated with sun exposure: reported duration (behavioral) and intensity (geographic location)...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
The objective of this study was to assess patient knowledge related to skin cancer at the San Juan Bosco clinic, a free clinic in Miami, Florida serving underinsured patients.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Detection bias is an important source of potential bias in epidemiologic studies in which more intensive surveillance is associated with a greater apparent risk of disease. To assess the potential for detection bias related to skin cancers, we examined the association between various health maintenance practices and squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma in Nurses Health Study (NHS) and Health Professionals Follow-up Study (HPFS), large US cohorts of women and men, respectively.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Light hair color is an established risk factor for melanoma. Whether hair color is associated with risk of keratinocyte carcinoma, also known as non-melanoma skin cancer, has not been thoroughly studied. We prospectively examined the association between natural hair color at adulthood and risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) based on a total 205,307 participants from the Nurses Health Study (NHS, n=78,879), NHS II (n=89,516), and Health Professionals Follow-up Study (HPFS, n=36,912).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
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