TYRP1 mRNA goes fishing for miRNAs in melanoma

Nature Cell Biology 19, 1311 (2017). doi:10.1038/ncb3637 Authors: Maria S. Soengas &Eva Hernando A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research

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This study aims to describe the profile of eyelid cancers and also to explicate the management strategies of eyelid cancers.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Ophthalmic Surgery Source Type: research
Lymphoscintigraphy (LS) is recommended prior to sentinel lymph node biopsy (SLNB) to improve accuracy. It has generally fallen out of favor in breast cancer; for logistical reasons it has historically been omitted for melanoma patients at our institution. We hypothesized that success of SLNB in extremity melanoma would be similar between LS and non-LS groups.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Surgical Oncology Source Type: research
The incidence and risk factors associated with upstaging from initial biopsy to definitive excision in cutaneous melanoma have not been established. The aim of our study was to determine the incidence of T stage upstaging of cutaneous melanoma and associated risk factors using the NCDB.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Surgical Oncology Source Type: research
Contributors : Masayoshi Suda ; Goro Katsuumi ; Tohru MinaminoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAccumulation of senescent cells in various tissues has been reported to have a pathological role in age-associated diseases. Inhibition of cellular aging signals prevents the onset of age-associated pathology, but there is a risk of promoting carcinogenesis. Elimination of senescent cells (senolysis) was recently reported to reversibly improve pathological changes related to aging in aged mice without increasing the development of cancer. Here we report that glycoprotein nonme...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
In conclusion, our study shows that there is an inverse correlation of the number of metastasis with the DFS and metastasized survival, indicating separate growth patterns. We also revealed that the number and type of metastases is irrelevant to the prognostic mutation status of the tumor, showing that both BAP1- and SF3B1-mutated UM can result in solitary and miliary metastases, indicating that other processes lay ground to the different metastatic patterns.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Cancers, Vol. 13, Pages 5301: Identification of MicroRNA–mRNA Networks in Melanoma and Their Association with PD-1 Checkpoint Blockade Outcomes Cancers doi: 10.3390/cancers13215301 Authors: Robert A. Szczepaniak Sloane Michael G. White Russell G. Witt Anik Banerjee Michael A. Davies Guangchun Han Elizabeth Burton Nadim Ajami Julie M. Simon Chantale Bernatchez Lauren E. Haydu Hussein A. Tawbi Jeffrey E. Gershenwald Emily Keung Merrick Ross Jennifer McQuade Rodabe N. Amaria Khalida Wani Alexander J. Lazar Scott E. Woodman Linghua Wang Miles C. Andrews Jennifer A. Wargo ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractAdvanced gastric cancers are responsible for overwhelming human suffering and death. Despite the development of combination chemotherapies, the survival rates of patients with gastric cancer remain unsatisfactory. Given the growing evidence of the benefits of immunotherapy as an alternative treatment for other cancers such as advanced melanoma, non-small cell lung cancer, renal cell carcinoma, and refractory Hodgkin ’s lymphoma, researchers have begun to explore its application in the treatment of gastric cancer. Three types of immunotherapy have shown promising effects against gastric cancer: immune checkpoi...
Source: Surgery Today - Category: Surgery Source Type: research
Conditions:   Advanced Solid Tumor;   Unresectable Solid Tumor;   Melanoma;   Renal Cell Carcinoma;   Sarcoma;   Triple Negative Breast Cancer;   Pancreatic Ductal Adenocarcinoma;   Non-Small Cell Lung Cancer Squamous;   Non-Small Cell Lung Cancer Non-squamous;   Colorectal Cancer ;   Gastric Cancer;   Biliary Tract Cancer;   Gallbladder Cancer;   Cholangiocarcinoma;   Uterine Cancer;   Ovarian Cancer;   Cervica...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Melanoma;   Skin Cancer Intervention:   Other: education Sponsor:   Herlev Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Advanced Solid Tumor;   Unresectable Solid Tumor;   Melanoma;   Renal Cell Carcinoma;   Sarcoma;   Triple Negative Breast Cancer;   Pancreatic Ductal Adenocarcinoma;   Non-Small Cell Lung Cancer Squamous;   Non-Small Cell Lung Cancer Non-squamous;   Colorectal Cancer ;   Gastric Cancer;   Biliary Tract Cancer;   Gallbladder Cancer;   Cholangiocarcinoma;   Uterine Cancer;   Ovarian Cancer;   Cervica...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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