TYRP1 mRNA goes fishing for miRNAs in melanoma

Nature Cell Biology 19, 1311 (2017). doi:10.1038/ncb3637 Authors: Maria S. Soengas &Eva Hernando A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research

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Matrix metalloproteinase and pH dual ‐sensitive micelles for anti‐PD‐1 antibody (aPD‐1) and paclitaxel (PTX) delivery are described. Sheddable polyethylene glycol (PEG) enhances the tumor accumulation of nanodrug and achieves intratumor immune activation. The nanodrug shows programmed site‐specific release of aPD‐1 and PTX in tumor tissue and tumor cells, respectively, resulting in a synergistic antitumor effect with chemoimmunotherapy. AbstractImmune checkpoint blockade (ICB) is demonstrating great potential in cancer immunotherapy nowadays. Yet, the low response rate to ICB remains an urgent challenge for tum...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Conclusions Results demonstrate how immunotherapy can impact the QoL of both patients and carers, either directly through toxicities or indirectly through mechanisms such as stress, financial toxicity, or fatigue that limits participation in life activities. Implications for Practice Supportive care resources and interventions are needed for those receiving immunotherapy to minimise negative impacts on QoL. Carers likewise require better preparation and information to assist in identifying potential treatment toxicities and ensure patient safety.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES: ONLINE ONLY Source Type: research
Rash is one of the most common severe adverse events associated with use of vemurafenib for the treatment of melanoma, either as monotherapy or in combination with cobimetinib. The study aimed to identify pre-...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
In conclusion, we show that optimization of CD8 TIL cell sorting strategy is a viable approach to improve recall capacity and in vivo persistence of transferred cells in the context of ACT.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: DiCaprio MR, Abousayed MM, Kambam MLR Abstract Melanoma is an aggressive form of skin cancer associated with significant morbidity and mortality. Although commonly seen in dermatologist clinics, orthopaedic surgeons must be aware of these lesions in various ways. The five common musculoskeletal manifestations of melanoma will be discussed as well as the epidemiology, pathogenesis, diagnosis, staging, treatment, and prognosis of melanoma. With an index of suspicion and awareness of melanoma, a thorough history and detailed physical examination are critical in establishing a diagnosis. An adequately performe...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC modulates anticancer immune responses is mostly unknown. Here, we show that a fully competent immune system is required to maximize the antiproliferative effect of VitC in breast, colorectal, melanoma, and pancreatic murine tumors. High-dose VitC modulates infiltration of the tumor microenvironment by cells of the immune system and delays cancer growth in a T cell–dependent manner. VitC not only enhances the cytotoxic activity of ad...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Cancers, Vol. 12, Pages 541: Molecular Profiling of Keratinocyte Skin Tumors Links Staphylococcus aureus Overabundance and Increased Human β-Defensin-2 Expression to Growth Promotion of Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12030541 Authors: Madhusudhan Pausan Halwachs Durdević Windisch Kehrmann Patra Wolf Boukamp Moissl-Eichinger Cerroni Becker Gorkiewicz The skin microbiota plays a prominent role in health and disease; however, its contribution to skin tumorigenesis is not well understood. We comparatively assessed the microbial community compositions from ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
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