TYRP1 mRNA goes fishing for miRNAs in melanoma
Nature Cell Biology 19, 1311 (2017).
doi:10.1038/ncb3637
Authors: Maria S. Soengas & Eva Hernando
A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.
Source: Nature Cell Biology - Category: Cytology Authors: Maria S. Soengas Eva Hernando Tags: News and Views Source Type: research