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PARPi focus the spotlight on replication fork protection in cancer

Nature Cell Biology 19, 1309 (2017). doi:10.1038/ncb3638 Author: Katharina Schlacher PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research

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BRF1, BRCA1/2, MPO induced by alcohol have prognostic value for patients with gastric cancer
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pathology, Journal, Source Type: news
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Source: Cell and Tissue Research - Category: Cytology Source Type: research
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Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(University of Edinburgh) Scientists have solved a longstanding puzzle of how cells are able to tightly package lengthy strands of DNA when they divide -- an essential process for growth, repair and maintenance in living organisms.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
When I was traveling in India, I had the privilege of studying Ayurvedic medicine with traditional Master Healers. Surrounded by lakes, oceans and mountains, Kerala, India, is the birthplace of Ayurveda medicine. My plane landed in Mumbai. From there, I made the 800-mile trip to Kerala down on the southwestern-most tip of the Indian peninsula. With origins dating back 6,000 years, Kerala is the birthplace of Ayurvedic medicine. I spent a lot of time at the AyurMana or “ancient healing house.” This is the oldest existing school of Ayurvedic medicine in the world. It was there that I observed how quickly...
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Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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