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RA Associated With Higher Risk of COPD Hospitalization

Risk is 47 percent higher in RA patients than general population after adjustment for confounders
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Pulmonology, Rheumatology, Journal, Source Type: news

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Authors: Köhler D, Dellweg D Abstract Numerous studies have shown that exacerbation rates in COPD can be significantly reduced by long acting beta-2-agonists (LABA), long acting anticholinergic agents (LAMA) and inhaled steroids (ICS). Elaborate and extensive investigations however failed to prove that the reduction in exacerbation rates leads to life prolongation. As opposed to this, numerous studies have shown a reduction in life expectancy with increasing number and severity of exacerbations.This review aimed at comparing these studies and to elaborate the relevance and reduction of exacerbations rates by L...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Overweight in patients with chronic obstructive pulmonary disease needs more attention: a cross-sectional study in general practice, Published online: 22 November 2017; doi:10.1038/s41533-017-0065-3Doctors should pay more attention to weight management in patients with mild chronic lung disease, say researchers in the Netherlands. While guidelines for treating chronic obstructive pulmonary disease (COPD) focus primarily on preventing weight-loss in severe COPD, around 65 per cent of patients with mild COPD are overweight or obese. Excessive weight exacerbates symptoms and triggers co-morbidities, and so can impact heavily ...
Source: npj Primary Care Respiratory Medicine - Category: Primary Care Authors: Source Type: research
Conclusions: Our findings provide robust evidence of higher nonaccidental and cardiovascular mortality in association with short-term exposure to ambient ozone in China. https://doi.org/10.1289/EHP1849 Received: 4 March 2017 Revised: 3 October 2017 Accepted: 20 October 2017 Published: 21 November 2017 Address correspondence to H. Kan, Department of Environmental Health, School of Public Health, Fudan University, P.O. Box 249, 130 Dong-An Road, Shanghai 200032, China. Telephone: 86 (21) 5423 7908. Email: kanh@fudan.edu.cn and M. Zhou, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chines...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
The risk is nearly twice as high as in the general population, and women are at significantly higher risk.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: COPD Rheumatoid Arthritis Source Type: news
Mitochondrial dysfunction and cellular senescence are two of the root causes of aging targeted by the SENS rejuvenation research programs. They overlap at least a little, in that one might cause the other, but it is unclear as to whether this is significant for the specific types of mitochondrial damage considered important in the SENS view of aging. The open access paper here walks through this territory in the case of the aging lung; in recent years, it has become clear that senescent cells are important in the development of fibrosis in lungs and other organs, as well as in other aspects of aging in lung tissue. The pre...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Objective: We use a single-alveolar-compartment model to describe the partial pressure of carbon dioxide in exhaled breath, as recorded in time-based capnography. Respiratory parameters are estimated using this model, and then related to the clinical status of patients with obstructive lung disease. Methods: Given appropriate assumptions, we derive an analytical solution of the model, describing the exhalation segment of the capnogram. This solution is parametrized by alveolar CO2 concentration, dead-space fraction, and the time constant associated with exhalation. These quantities are estimated from individual capnogram d...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
The prevalence of chronic obstructive pulmonary disease (COPD) and its associated comorbidities increase with age. However, little is understood about differences in the disease in patients over 65  years of age compared with younger patients.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Original Study Source Type: research
Patients with chronic obstructive pulmonary disease (COPD) can be classified into groups A/C or B/D based on symptom intensity. Different threshold values for symptom questionnaires can result in misclassification and, in turn, different treatment recommendations. The primary aim was to find the best fitting cut-points for Global initiative for chronic Obstructive Lung Disease (GOLD) symptom measures, with an modified Medical Research Council dyspnea grade of 2 or higher as point of reference.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: JAMDA Online Source Type: research
BACKGROUND AND OBJECTIVES: The prevalence of chronic obstructive pulmonary disease (COPD) in Saudi Arabia is unknown. The aim of this study was to estimate the prevalence of COPD among smokers more than 40 years of age attending primary healthcare clinics in Saudi Arabia. DESIGN AND SETTING: A questionnaire was used in a cross-sectional collection of demographic data and other items related to diagnosis of COPD in patients visiting primary healthcare clinics. METHODS: Eligible subjects were current or ex-smokers and aged 40 years or above. Spirometry was performed according to American Thoracic Society criteria. ...
Source: Annals of Saudi Medicine - Category: General Medicine Tags: ISSUE 2 Source Type: research
Chronic obstructive pulmonary disease (COPD) affects over 65 million individuals worldwide, where α-1-antitrypsin deficiency is a major genetic cause of the disease. The α-1-antitrypsin gene, SERPINA1, expresses an exceptional number of mRNA isoforms generated entirely by alternative splicing in the 5′-untranslated region (5′-UTR). Although all SERPINA1 mRNAs encode exactly the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
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