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Promising Pneumonia Vaccine Under Development

Animal tests showed an immune response to 72 of the 90 - plus known strains of S. pneumoniae
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Emergency Medicine, Pediatrics, Pulmonology, Journal, Source Type: news

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Publication date: Available online 9 November 2017 Source:International Journal of Veterinary Science and Medicine Author(s): Victor O. Oyebanji, Benjamin O. Emikpe, Omolade A. Oladele, Oyedeji I. Osowole, Adebayo Salaam, Michael A. Odeniyi, Olajide Kasali, Oluwole A. Akinboade Following previous studies delivery potential and immune response of chickens given Newcastle disease vaccine with gums, this study was conducted to evaluate the protective ability of vaccines delivered with plant gums in against clinicopathological features of Newcastle disease (ND). Processed gums from incised trunks of Cedrela odorata and Khaya ...
Source: International Journal of Veterinary Science and Medicine - Category: Veterinary Research Source Type: research
Authors: Haas B, Grenier D Abstract Streptococcus suis is a major swine pathogen worldwide and causes considerable economic losses in the swine industry. S. suis is also an emerging zoonotic agent, mainly in Asia. In pigs and humans, S. suis can cause septicemia, pneumonia, endocarditis, arthritis, and meningitis with irreversible sequelae. Identification and characterization of the virulence factors produced by S. suis are major advances in the understanding of the pathogenesis of S. suis infections and has therefore opened promising avenues for vaccine development against this pathogen. This litera...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
AbstractAchieving the control of bovine tuberculosis (bTB) would require the discovery of an efficient combined immunodiagnostic and vaccine strategy. Since in vivo experiments on cattle are not ethically and economically acceptable there is a need for a cost-effective animal model capable of reproducing, as closely as possible, the physiopathology of bTB to (i) better characterize the cellular and molecular features of bTB immunopathogenesis and (ii) screen preclinical vaccine candidates. To develop such a model, we focused on the C3HeB/FeJ Kramnik ’s mouse forming hypoxic, encapsulated granulomas with a caseous nec...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
This study evaluated the therapeutic antiviral effects of PUL-042 against established influenza A pneumonia, when given alone or in combination with oseltamivir. Mice were treated with PUL-042 aerosol, oseltamivir or both at varying time points before or after challenge with influenza pneumonia. Treating established, otherwise lethal influenza A pneumonia (>1 LD100) with multiple inhaled doses of PUL-042 aerosol plus oral oseltamivir resulted in greater mouse survival than treatment with either drug alone. Single agent PUL-042 also protected mice against established infections following challenges with lower viral inocu...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Posters: Misuse of antibiotics and risks. Credit: WHOBy Baher KamalROME, Oct 4 2017 (IPS)The world is running out of new antibiotics to combat the growing threat of antimicrobial resistance, a new specialised report warns ahead of this year’s World Antibiotic Awareness Week, adding that most of the drugs currently in the clinical pipeline are modifications of existing classes of antibiotics and are only short-term solutions. The latest World Health Organization (WHO) report on this issue “Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline, includi...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health Human Rights TerraViva United Nations Source Type: news
This study will help to characterize the relationship between recombination and evolution of PRRSV.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
The objective of this study was to evaluate the survival of a M. bovis isolate following nebulisation and to establish whether respiratory disease similar to that seen in the field could be induced in calves by exposing them to an aerosolised culture of M. bovis. A group of eight M. bovis-free calves 14–28days old were exposed to an aerosolised culture of a field isolate of M. bovis that had originally been recovered from a joint lesion in a calf. Three weeks after aerosol exposure necropsies were conducted on all calves. Lung lesions were seen in 7 of 8 calves exposed to the aerosol of M. bovis, whilst calves expose...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Mycoplasma hyopneumoniae (Mhp) causes porcine enzootic pneumonia, a disease that cause major economic losses in the pig industry. Dendritic cells (DCs), the most effective antigen-pres...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
This study assessed the...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
Summary Mycoplasma hyopneumoniae (M. hyopneumoniae) is the primary pathogen of enzootic pneumonia, a chronic respiratory disease in pigs. Infections occur worldwide and cause major economic losses to the pig industry. The present paper reviews the current knowledge on M. hyopneumoniae infections, with emphasis on identification and analysis of knowledge gaps for optimizing control of the disease. Close contact between infected and susceptible pigs is the main route of M. hyopneumoniae transmission. Management and housing conditions predisposing for infection or disease are known, but further research is need...
Source: Transboundary and Emerging Diseases - Category: Veterinary Research Authors: Tags: DISCONTOOLS SUPPLEMENT Source Type: research
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