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Promising Pneumonia Vaccine Under Development

Animal tests showed an immune response to 72 of the 90 - plus known strains of S. pneumoniae
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Emergency Medicine, Pediatrics, Pulmonology, Journal, Source Type: news

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The San Francisco SPCA announced Friday on Twitter that cases of dog flu had been confirmed in the Bay Area, and encouraged dog owners to contact their veterinarians if their pets display symptoms of the virus. California is one of several states that has reported outbreaks of dog flu, also known as canine influenza, over the past several months. The Cornell University College of Veterinary Medicine, which monitors reports of dog flu around the country, confirmed that six dogs have tested positive for the canine influenza H3N2 virus in California in the last 45 days. Although there is also an H3N2 strain of human seasonal ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Can a dog get the flu Can dogs get the flu Can you give your dog the flu Dog flu 2018 Dog flu symptoms Dog flu symptoms and treatment dog flu vaccine healthytime public health Signs of dog flu Symptoms of dog flu the Source Type: news
Discussion This case study illustrated not only the veracity of the maxim “chance favors the prepared mind” exquisitely because of the judicious, albeit auspicious, identification of the assiduous bacterium by the owner’s veterinarian, but also the high level of patient care that can potentially be achieved when veterinary personnel actively foster working relationships with their local public health counterparts. In this case, the owner was prophylactically treated with doxycycline for F. tularensis exposure within 24 hours of being bitten and given the rabies post-exposure prophylaxis (human rabies imm...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
Publication date: Available online 10 January 2018 Source:Research in Veterinary Science Author(s): Bernadette Earley, Katie Tiernan, Catherine Duffy, Amanda Dunn, Sinead Waters, Steven Morrison, Mark McGee The study objectives were: 1) to characterise the development of immunocompetence in beef suckler calves from birth to three months of age, and 2) to trace glycoprotein E (gE)-negative bovine herpesvirus type 1 (BoHV-1) antibodies from dam to calf and subsequent vaccination against pneumonia. Thirty multiparous beef suckler, spring-calving cows, consisting of two genotypes were involved; Limousin×Friesian (LF) an...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
In this study, an inactivated vaccine containing a mixture of M. hyorhinis and M. hyopneumoniae was generated and evaluated for safety, immunogenicity, and protective efficacy against challenge with M. hyorhinis in pigs. The inactivated vaccine induced an antibody response and reduced pneumonic lesions in the lungs and tracheas compared with the non-vaccinated group.
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
In conclusion, FH-Fc chimeric proteins could serve as adjunctive treatments against multidrug-resistant bacterial infections. PMID: 29084837 [PubMed - indexed for MEDLINE]
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities. The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
My attention was drawn today to a recently published presentation by James Peyer. He heads up Apollo Ventures, one of the new crop of investment concerns focused on funding companies that are developing means to treat aging. These include the Longevity Fund, first out of the gate some years ago, as well as Juvenescence and the Methuselah Fund, created this year, and a repurposing of existing funds, such as Michael Greve's Kizoo ventures. Apollo Ventures is the source of the Geroscience online magazine that helps to advance and explain the position taken on aging by this group; this is something that more investors should d...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models. Biomaterials. 2017 Nov 20;155:152-164 Authors: Wu J, Wu K, Xu W, Yuan T, Wang X, Zhang J, Min Y, Yin Y, Zhang X Abstract Vaccine design ushered in the era of nanotechnology, as the vaccine is being developed toward particulate formulation. We have previously shown that the attenuated pneumolysin mutant (ΔA146PLY) was a safe and effective pneumococcal vaccine candidate. Here, to further optimize the formulati...
Source: Biomaterials - Category: Materials Science Authors: Tags: Biomaterials Source Type: research
Publication date: Available online 9 November 2017 Source:International Journal of Veterinary Science and Medicine Author(s): Victor O. Oyebanji, Benjamin O. Emikpe, Omolade A. Oladele, Oyedeji I. Osowole, Adebayo Salaam, Michael A. Odeniyi, Olajide Kasali, Oluwole A. Akinboade Following previous studies delivery potential and immune response of chickens given Newcastle disease vaccine with gums, this study was conducted to evaluate the protective ability of vaccines delivered with plant gums in against clinicopathological features of Newcastle disease (ND). Processed gums from incised trunks of Cedrela odorata and Khaya ...
Source: International Journal of Veterinary Science and Medicine - Category: Veterinary Research Source Type: research
Authors: Haas B, Grenier D Abstract Streptococcus suis is a major swine pathogen worldwide and causes considerable economic losses in the swine industry. S. suis is also an emerging zoonotic agent, mainly in Asia. In pigs and humans, S. suis can cause septicemia, pneumonia, endocarditis, arthritis, and meningitis with irreversible sequelae. Identification and characterization of the virulence factors produced by S. suis are major advances in the understanding of the pathogenesis of S. suis infections and has therefore opened promising avenues for vaccine development against this pathogen. This litera...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
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