Promising Pneumonia Vaccine Under Development

Animal tests showed an immune response to 72 of the 90 - plus known strains of S. pneumoniae
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Emergency Medicine, Pediatrics, Pulmonology, Journal, Source Type: news

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Publication date: Available online 13 June 2018 Source:Preventive Veterinary Medicine Author(s): Louis Lignereux, Anne-Lise Chaber, Claude Saegerman, Lucía Manso-Silván, Armelle Peyraud, Andrea Apolloni, François Thiaucourt Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae, has long been considered a goat-specific disease. Since 2007 there has been growing evidence that this disease can affect wild ungulates either kept in captivity or in the wild. In 2013, a large collection of sand gazelles (Gazella marica) held in the United Arab Emirates suffered hea...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Streptococcus pneumoniae (S. pneumonia), bacteria commonly referred to as pneumococcus, are a significant cause of disease resulting in 1.5 million deaths every year worldwide according to the World Health Organization. The major types of pneumococcal disease are pneumonia (lung infection), bacteremia (bloodstream infection), and meningitis (infection of the tissue covering of the brain and spinal cord). Less severe pneumococcal illnesses include ear and sinus infections.CDC scientists have developed a specific amino acid sequence, the P4 peptide, of the Pneumococcal surface adhesin A (PsaA) protein which is an immunogenic...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
aki Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. It has been developed as vaccine carriers for the prevention of lifestyl...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
This study aimed at identifying challenges facing producers of small ruminants, prioritizing diseases and their control measures and documenting opportunities for improvement. Sixteen focus group dis cussions with livestock owners and 13 key informant interviews were done in selected areas in Mandera County, Northern Kenya, and both quantitative and qualitative data collected using a questionnaire guide. Occurrences of diseases (27.4%) and drought (25%) were consistently ranked high in all group s. Other production challenges included increased predation of livestock, inadequate delivery of veterinary services, and increas...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
In this study, we administered specially developed chitosan/alginate nanoparticle encapsulated BV (CH/AL-BV) which has slow-releasing properties and mucosal adhesiveness to pig via nasal route and evaluate whether it can facilitate systemic immune response and improve clearance of porcine reproductive and respiratory syndrome virus (PRRSV). The CH/AL-BV-administered group with PRRSV vaccination showed significantly enhanced Th1-related responses including a high population of CD4+ T lymphocyte and cytokine mRNA levels including interferon-gamma (IFN-γ) and interleukin (IL)-12 and increased PRRSV-specific IgG levels. ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
This study evaluates the prevalence of important bacterial pathogens associated with caprine pneumonia in Nigeria using cultural and immunohistochemical techniques. One hundred and fifty goat lungs were randomly examined from macroscopic, cultural isolation and microscopic changes using standard techniques. The common bacteria identified were formalin inactivated for bacterine and polyclonal antibody production. Immunohistochemical staining was performed against the bacteria antigens using the avidin-biotin peroxidase complex technique. The data were presented in frequencies and percentages, and compared using non-parametr...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
Abstract Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical candidates advance, cotton rats (Sigmodon hispidus) and non-human primates (NHP) continue to play a valuable role in RSV vaccine development, since both animals are semi-permissive to human RSV (HRSV). However, appropriate utilization of the models is critical to avoid mis-interpretation of the preclinical findings. Using a multimodality imaging approach; a fluore...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
The San Francisco SPCA announced Friday on Twitter that cases of dog flu had been confirmed in the Bay Area, and encouraged dog owners to contact their veterinarians if their pets display symptoms of the virus. California is one of several states that has reported outbreaks of dog flu, also known as canine influenza, over the past several months. The Cornell University College of Veterinary Medicine, which monitors reports of dog flu around the country, confirmed that six dogs have tested positive for the canine influenza H3N2 virus in California in the last 45 days. Although there is also an H3N2 strain of human seasonal ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Can a dog get the flu Can dogs get the flu Can you give your dog the flu Dog flu 2018 Dog flu symptoms Dog flu symptoms and treatment dog flu vaccine healthytime public health Signs of dog flu Symptoms of dog flu the Source Type: news
Discussion This case study illustrated not only the veracity of the maxim “chance favors the prepared mind” exquisitely because of the judicious, albeit auspicious, identification of the assiduous bacterium by the owner’s veterinarian, but also the high level of patient care that can potentially be achieved when veterinary personnel actively foster working relationships with their local public health counterparts. In this case, the owner was prophylactically treated with doxycycline for F. tularensis exposure within 24 hours of being bitten and given the rabies post-exposure prophylaxis (human rabies imm...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
Publication date: Available online 10 January 2018 Source:Research in Veterinary Science Author(s): Bernadette Earley, Katie Tiernan, Catherine Duffy, Amanda Dunn, Sinead Waters, Steven Morrison, Mark McGee The study objectives were: 1) to characterise the development of immunocompetence in beef suckler calves from birth to three months of age, and 2) to trace glycoprotein E (gE)-negative bovine herpesvirus type 1 (BoHV-1) antibodies from dam to calf and subsequent vaccination against pneumonia. Thirty multiparous beef suckler, spring-calving cows, consisting of two genotypes were involved; Limousin×Friesian (LF) an...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
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