Age ‐related reduction of dermal fibroblast size upregulates multiple matrix metalloproteinases as observed in aged human skin in vivo

ConclusionsCombined actions of the wide variety of MMPs that are constitutively elevated in aged dermis may be involved in the progressive degradation of dermal collagen fibrils. Age‐related elevations of multiple MMPs are likely to be a result of the reduction of fibroblast size via activation of AP‐1.
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Translational Research Source Type: research