Doctors face legal action over use of unlicensed eye drug

They want to prescribe Avastin for wet AMD rather than costlier alternatives Related items fromOnMedica UK patients losing out in access to cancer drugs Drug and Therapeutics Update UK ‘inadequate’ at regulating off-label drugs GMC steps into eye drug row Novartis accused of attempt to derail eye drug trials
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Publication date: June 2019Source: Microchemical Journal, Volume 147Author(s): Linshun Xie, Tianhua Li, Futao Hu, Qianli Jiang, Qiqin Wang, Ning GanAbstractTo detect trace level of tumor markers (TMs) plays a crucial role in the early diagnosis of cancer. However, the fabrication of assays to simultaneously detect trace levels of TMs was still challengeable. The study was aimed to develop a novel microchip electrophoresis (MC) and antibody-aptamer based hybrid detection strategy for simultaneous determination of prostate specific antigen (PSA), carcino-embryonic antigen (CEA) and carbohydrate antigen 125 (CA125) in human s...
Source: Microchemical Journal - Category: Chemistry Source Type: research
This study demonstrates that ROS-responsive TEP NPs are effective drug carriers for efficient intracellular delivery of hydrophobic drug, PL.Graphical abstractROS-responsive thioether-bearing polymers (TEP) were synthesized and used as drug carriers for intracellular delivery of piperlongumine (PL) in cancer cells. The PL-loaded TEP nanoparticles exhibited ROS-triggered disassembly in cancer cells, leading to efficient cancer cell-specific apoptosis.
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
The objectives—and perhaps even more interesting, the disparities within the objectives according to sex, educational attainment and disability status—are tracked by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics. We can search the CDC’s database by topic area for additional data on health care disparities. While the government works toward the Healthy People initiative, we can help improve health care access for those with communication disorders in our communities. I started by considering people’s social determinants of health in my community an...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Audiology Health Care Private Practice Slider Speech-Language Pathology hearing loss Language Disorders Speech Disorders Source Type: blogs
We describe the overall safety and tolerability profiles based on a literature review of all published phase I and II clinical trials in this setting. Drug exposure, tumour mutational status and metastases resectability are discussed. A review of pubmed and abstracts of major oncology congresses from 2009 to 2018, with MeSH and full-text search terms for clinical trials of anti-EGFR for "metastatic" or "advanced" "colorectal cancer/adenocarcinoma" was implemented. Only English language publications were included. Expert opinion: Efficacy data from phase II trials are promising, but the safety ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
In conclusion, we confirmed that the highly selective dual enzyme immunoassays can be applied as a new analytical method capable of early diagnosing and monitoring colon and pancreatic cancers with the simultaneous analyses of CA 19-9 and CEA. PMID: 30902335 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract The development of cost-effective methods for early detection and identification of prognostic markers still remains a significant challenge to improve diagnosis and reduce the mortality of cancer. Herein, on the basis of rolling circle amplification (RCA) coupled with nicking endonuclease-assisted signal amplification (NESA), a simple, sensitive and portable biosensor was developed for the determination of p53 DNA by using the personal glucose meter (PGM) as readout. Initially, biotin-modified hairpin probe (HP) was immobilized onto streptavidin-coated magnetic beads (MBs). The target DNA hybridized with...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
More than half of the people in the world host colonies of a bacterium called Helicobacter pylori in their stomachs.Although it ’s harmless to many, H. pylori can cause stomach cancer as well as ulcers and other gastric conditions. Doctors tend to prescribe multiple antibiotics to defeat the microbe, but that strategy can lead to antibiotic-resistant superbugs.Now, afinding by UCLA scientists may lead to a better approach. The researchers have determined the molecular structure of a protein that enables H. pylori to stay alive in the stomach, and elucidated the mechanism by which that protein works.Z. Hong Zhou, the ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSIONS: Patients with congenital IGHD who do not receive early and regular replacement treatment are prone to lag in achieving normal height and suffer from educational and vocational handicaps. PMID: 30905105 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Publication date: Available online 25 March 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Da Kyung Hong, Seon Ah Kim, Kyung Taek Lim, Ki Heon Lee, Tae Jin Kim, Kyeong A. SoAbstractObjectiveTo investigate the clinical outcome of high-grade cervical intraepithelial neoplasia (CIN) diagnosed by colposcopy-directed biopsy during pregnancy and to evaluate the risk factors for persistent disease.Study DesignThis retrospective study included pregnant women who were diagnosed with CIN2+ by colposcopy-directed biopsy from January 2005 to December 2014. The clinical characteristics, hi...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Diseases linked to vitamin D deficiency include cardiovascular disease, diabetes and cancer. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Nutrition Source Type: blogs
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