Theravance Biopharma and Mylan Report Additional Positive Phase 3 Data for Revefenacin (TD-4208) in Multiple Presentations at 2017 CHEST Annual Meeting

Presentations Highlight 24-Hour Serial Spirometry Subgroup Findings from Two Replicate Pivotal Phase 3 Studies; Improvements Observed in St. George's Respiratory Questionnaire and COPD Assessment Test Results DUBLIN and HERTFORDSHIRE, England and PITTS... Biopharmaceuticals Theravance Biopharma, Mylan, Revefenacin, COPD
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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People living with HIV (PLWH) may be more susceptible to the development of emphysema than uninfected individuals. We assessed prevalence and risk factors for emphysema in PLWH and uninfected controls. Spirometry and chest computed tomography scans were obtained in PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and in uninfected controls from the Copenhagen General Population Study (CGPS) who were>40 years. Emphysema was quantified using a low attenuation area 10%) by PD15 or by visually assessed emphysema. We found no interaction between HIV and cumulative smoking. Breathlessness and sputum p...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Lung imaging Original Articles: Thoracic imaging Source Type: research
GPs should consider spirometry testing for patients who are incidentally found to have signs of COPD on a chest X-ray or CT scan.
Source: NHS Networks - Category: UK Health Source Type: news
This study aimed to investigate the effect of Liuzijue exercise combined with elastic band resistance exercise on patients with chronic obstructive pulmonary disease (COPD) to provide a convenient, safe, and cost-effective exercise. Methods: Subjects were randomly divided into the control group (CG), the Liuzijue exercise group (LG), and the Liuzijue exercise combined with elastic band resistance exercise group (LEG), with 20 patients in each group. The LG performed Liuzijue exercise six times a week (two exercise sessions in the hospital and four exercise sessions at home). The LEG includes Liuzijue exercise similar t...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: July 2018Source: The Lancet Respiratory Medicine, Volume 6, Issue 7Author(s): Danielle C M Belgrave, Raquel Granell, Steve W Turner, John A Curtin, Iain E Buchan, Peter N Le Souëf, Angela Simpson, A John Henderson, Adnan CustovicSummaryBackgroundMaximal lung function in early adulthood is an important determinant of mortality and COPD. We investigated whether distinct trajectories of lung function are present during childhood and whether these extend to adulthood and infancy.MethodsTo ascertain trajectories of FEV1, we studied two population-based birth cohorts (MAAS and ALSPAC) with repeat spirometr...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
ConclusionThe annual decline in FEV1 was most significant in smokers with mild airflow obstruction in a Japanese general population. This highlights the importance of early detection of chronic obstructive pulmonary disease patients among the general population in order to prevent disease progression in undiagnosed patients.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Abstract Chronic obstructive pulmonary disease (COPD) is regarded as one of the leading causes of morbidity and mortality across the world, yet its proper diagnosis remains a challenge. Community-based population studies conducted in North and South America, Europe, Australia and Asia have revealed that 10%-12% of adults ≥ age 40 have evidence of persistent airflow limitation on spirometry, but only 20-30% of these subjects have been diagnosed with COPD. These studies collectively suggest that approximately 70% of COPD worldwide is under-diagnosed. Conversely other studies have shown that between 30-60% of pati...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Publication date: July 2018Source: The Lancet Respiratory Medicine, Volume 6, Issue 7Author(s): Danielle C M Belgrave, Raquel Granell, Steve W Turner, John A Curtin, Iain E Buchan, Peter N Le Souëf, Angela Simpson, A John Henderson, Adnan CustovicSummaryBackgroundMaximal lung function in early adulthood is an important determinant of mortality and COPD. We investigated whether distinct trajectories of lung function are present during childhood and whether these extend to adulthood and infancy.MethodsTo ascertain trajectories of FEV1, we studied two population-based birth cohorts (MAAS and ALSPAC) with repeat spirometr...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
ConclusionThe annual decline in FEV1 was most significant in smokers with mild airflow obstruction in a Japanese general population. This highlights the importance of early detection of chronic obstructive pulmonary disease patients among the general population in order to prevent disease progression in undiagnosed patients.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
ConclusionCorrelations between airway parameters and lung function tests vary widely between lobes, bronchus generations and breathing states. Our work suggests that the third generation bronchus of the upper left lobe in expiration could be the preferred localization for airway quantification in future studies.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Abstract BACKGROUND: High N-terminal pro-brain natriuretic peptide (NT-proBNP) during COPD exacerbations is associated with worse clinical outcomes. The prognostic value of NT-proBNP measured during clinical stability has not been well characterized. METHODS: We studied SPIROMICS participants 40-80 years of age with COPD GOLD spirometric stages 1-4. The association between baseline NT-proBNP and incident COPD exacerbations within one year of follow-up was tested using zero-inflated Poisson regression models adjusted for age, gender, race, body mass index, current smoking status, smoking history, FEV1 percent ...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Source Type: research
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