Theravance Biopharma and Mylan Report Additional Positive Phase 3 Data for Revefenacin (TD-4208) in Multiple Presentations at 2017 CHEST Annual Meeting

Presentations Highlight 24-Hour Serial Spirometry Subgroup Findings from Two Replicate Pivotal Phase 3 Studies; Improvements Observed in St. George's Respiratory Questionnaire and COPD Assessment Test Results DUBLIN and HERTFORDSHIRE, England and PITTS... Biopharmaceuticals Theravance Biopharma, Mylan, Revefenacin, COPD
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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Conclusions: The changes of surface EMGdi parameters had a direct correlation with classical measures in the whole cohort of AECOPD. The measurement of NRD by surface EMGdi represents a practical physiological biomarker, which may be helpful in detecting patients who should be hospitalized timely. PMID: 30511682 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 3 December 2018Source: Academic RadiologyAuthor(s): Kai Ruppert, Kun Qing, James T. Patrie, Talissa A. Altes, John P. MuglerRationale and ObjectivesHyperpolarized xenon-129 magnetic resonance (MR) provides sensitive tools that may detect early stages of lung disease in smokers before it has progressed to chronic obstructive pulmonary disease (COPD) apparent to conventional spirometric measures. We hypothesized that the functional alveolar wall thickness as assessed by hyperpolarized xenon-129 MR spectroscopy would be elevated in clinically healthy smokers before xenon MR diffusion measure...
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 1 December 2018Source: Indian Heart JournalAuthor(s): Tomoko Tomioka, Kento Fukui, Syuhei Tanaka, Yoshitaka Ito, Hiroki Shioiri, Jiro Koyama, Kanichi InoueAbstractBackgroundChronic obstructive pulmonary disease (COPD), a known risk factor for the development of congestive heart failure (CHF), was recently shown to predict the prevalence of atrial fibrillation (AF). Here, we explore the influence of AF on cardiac prognosis in COPD patients.MethodsA total of 339 consecutive patients who underwent spirometry from 2010 to 2013 for various reasons were retrospectively examined. Based on the di...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
AbstractChronic obstructive pulmonary disease (COPD) often goes unrecognised resulting in people living with the disease without a diagnosis. Screening of asymptomatic individuals is not recommended but case ‐finding is encouraged to detect early disease. We investigated the characteristics, symptom burden and flow of participants taking part in a community‐based COPD screening initiative in a city with high smoking prevalence.Screening was undertaken during four events in public locations over a 2 ‐week period. Participants completed symptom questionnaires and FEV‐1/FEV‐6 measurement. The criteria for being cons...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Authors: Eriksson B, Backman H, Ekerljung L, Axelsson M, Lindberg A, Rönmark E, Lundbäck B Abstract Cardiovascular diseases are the most common comorbidities in COPD, due to common risk factors such as smoking. The prevalence of current smokers in Sweden has decreased over four decades to around 10%. The aim of the present study was to investigate the prevalence, distribution and associations of cardiovascular comorbidities in COPD by disease severity in two large areas of Sweden, both with low-smoking prevalence. Data from clinical examinations in 2009-2012, including spirometry and structured interview,...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Authors: Lanza FC, Castro RAS, de Camargo AA, Zanatta DJM, Rached S, Athanazio R, Cukier A, Stelmach R, Dal Corso S Abstract The COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremen...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
ConclusionAs the variability of LA3rd and LA4th is greater than that of spirometric measurements, clinical studies should include cohorts with larger numbers of patients when considering LA than when considering spirometric measurements as end points.
Source: Academic Radiology - Category: Radiology Source Type: research
Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
Conclusion: Bronchodilator delivery via HFNC is similarly effective as MDI with spacer. Standard label dose (2.5mg) of albuterol via HFNC is sufficient to cause bronchodilation for asthma and COPD patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
Conclusions: We have identified a population of LR-MSC in patients with COPD and controls. These cells present abnormalities in their immunomodulatory capacity in relation COPD and current smoking.Supported in part by: FIS CP16/00039, PI15/00799, SEPAR 2015/068.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Mechanisms of Lung Injury and Repair Source Type: research
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