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Theravance Biopharma and Mylan Report Additional Positive Phase 3 Data for Revefenacin (TD-4208) in Multiple Presentations at 2017 CHEST Annual Meeting

Presentations Highlight 24-Hour Serial Spirometry Subgroup Findings from Two Replicate Pivotal Phase 3 Studies; Improvements Observed in St. George's Respiratory Questionnaire and COPD Assessment Test Results DUBLIN and HERTFORDSHIRE, England and PITTS... Biopharmaceuticals Theravance Biopharma, Mylan, Revefenacin, COPD
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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Conclusions: The increased expression of TLR2 and TLR4 suggests its role in disease pathogenesis of COPD. Smoke pack years was negatively associated with spirometric parameters in COPD patients. This may help to predict the smokers without COPD who risk developing the condition in the future. PMID: 29218124 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Aim: To study the effect of bronchial obstruction on clinical features and treatment effectiveness in patients with coronary heart disease (CHD) with cardiac insufficiency in persons, exposed to ionizing radiation. The study included 72 patients with CHD, exposed to ionizing radiation, who were admitted to hospital for cardial insufficiency. Conducted physical examination, chest x-ray, spirometry, echocardiography, electrocardiogram, clinical blood tests, evaluation of dyspnea scale MMRC, BMI.Results: Patients with cardial insufficiency 43 (59.7 %) revealed different degrees of (II-III) obstructive or mixed (obstructive-re...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Introduction: The "European COPD Audit" initiated by the European Respiratory Society (ERS) evaluated the management of hospital admissions due to exacerbation of COPD in several European Countries. Data on the treatment of severe acute exacerbation of COPD (AECOPD) in Switzerland is scarce. In light of the current guidelines, this work aimed to examine the quality of care for AECOPD and to provide specific recommendations for the management of severe AECOPD in Switzerland.Methods: 295 patients requiring hospital admission to 19 Swiss hospitals due to exacerbation of COPD during a predefined 60-day period, were i...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems COPD Source Type: research
Conclusions: Multi-omics integration facilitated 100% correct classification of COPD diagnosis in the presence of a strong confounder such as current smoking, with sub-groups of n=7.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
Conclusions: Improving COPD severity was associated with reduced mortality and worsening COPD severity was associated with increased mortality. Change in GOLD group has potential as monitoring tool and outcome measure in clinical trials.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Exhaled NO (FENO) is affected by airway inflammation, smoking and inhaled corticosteroid treatment, conditions common in COPD. In addition, about 15-20% of COPD-patients have features of asthma that may affect FENO.At the inclusion of the 2-year prospective COPD-study patients performed FENO50, exhaled CO and spirometry. CRP and blood cells were assessed. Exacerbations and symptoms were assessed by questionnaire, COPD Assessment Tool (CAT) and COPD Clinical Questionnaire (CCQ). Patients (n=533), 58% female, age 68±8 years, 34% reported asthma and 25% frequent exacerbations (≥ 2 or 1 exacerbation with hospital adm...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Conclusion: The disease activity defined by FEV1 is changeable over time in long-term COPD survivors.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Conclusion: Microspirometers are sensitive tools for screening adults for COPD.Higher cutoff values of FEV1/FEV6 were associated with increased sensitivity, as were strategies targeting smokers and a concomitant use of screening questionnaires.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Background: Occupational hazards are important, preventable causes of COPD but the high-risk occupations are uncertain. In an analysis of current occupation in the UK Biobank cohort we reported 14 jobs of increased risk (De Matteis, S. et al. OEM 2016).Aims and Objectives: Our aim was to develop these findings using lifetime job-histories to identify occupations at increased COPD risk, taking into account potential confounders.Methods: We used OSCAR, an online tool that automatically codes full job-histories using the UK Standard Occupational Classification (SOC) v.2000 (De Matteis, S. et al. SJWEH 2016). In 2016 we admini...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and Environmental Health Source Type: research
Conclusions: Occupational exposures in men with COPD were associated with slower decline of lung function.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and Environmental Health Source Type: research
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