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Dupilumab Breathes Optimism Into Biologics for Asthma Dupilumab Breathes Optimism Into Biologics for Asthma

Patients with severely uncontrolled asthma derive the most benefit from dupilumab, a new study shows, building enthusiasm for phase 3 results.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

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Publication date: Available online 24 February 2018 Source:Nitric Oxide Author(s): Marita Nittner-Marszalska, Anna Dor-Wojnarowska, Anna Wolańczyk-Mędrala, Anna Rosner-Tenerowicz, Mariusz Zimmer, Julia Dobek, Krzysztof Gomułka, Anna Parużyńska, Bernard Panaszek It has been reported that female sex hormones influence on allergic inflammation and ventilation parameters in asthma but conclusions drawn by different researchers are divergent. The aim of our study was to assess the impact of progesterone (Pg) and estradiol (E) on the dynamics of allergic inflammation and spirometry test results in regularly menstruating wo...
Source: Nitric Oxide - Category: Chemistry Source Type: research
This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary: Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma. Morbidity from asthma is increased during treatment. Overall, patients treated in clinical practice have worse baseline characteristics and comparable clinical outcomes to trial data. Follow-up studies provide reassurance on long-term safety. D...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Perciaccante A, Charlier P, Negri C, Coralli A, Appenzeller O, Bianucci R Abstract A1AT deficiency- a genetically inherited autosomal codominant disease with more than 120 identified alleles- was first identified by Laurell and Eriksson in 1963. The most common hereditary disorder in adults, A1AT causes an increased risk of developing pulmonary emphysema and liver disease. In A1AT patients, lung disease generally presents at a younger age than "usual" chronic obstructive pulmonary disease (COPD) and it may be misdiagnosed as asthma. Because A1AT deficiency patients can show the same clinical feat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This study presents a rational design approach to discovery synthetic peptide vaccine candidates from endogenous proteins for chronic non-infectious diseases immunological therapeutics. The approach described the screening of key antigenic amino acid residues of the interleukine-13, which is up-regulated expression in asthma, followed by the development of immunological helper epitope peptides via an integrative computational and experimental method. Notably, this totally synthetic peptide vaccine was capable of stimulating humoral immune responses much stronger than those of parental antigenic peptides by enhancing the ef...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
SATURDAY, Feb. 24, 2018 -- Your children may already be looking forward to summer camp. But when it comes to kids with asthma or allergies, parents need to take extra steps in planning their outdoor experience. " Kids with allergies and asthma need...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Authors: Hanefeld C, Haschemi A, Lampert T, Trampisch HJ, Mügge A, Miebach J, Kloppe C, Klaaßen-Mielke R Abstract BACKGROUND: Persons of lower socio-economic status are at higher risk of disease, especially with respect to severe and chronic illnesses. To date, there have not been any studies with large case numbers regarding acute medical emergencies in this population. METHODS: In a retrospective study, data were obtained on all cases treated by emergency physicians in Bochum, Germany, in 2014/2015, including the diagnoses that were made by the emergency physicians. There were a total of 16 767 cas...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Publication date: 13 February 2018 Source:Cell Reports, Volume 22, Issue 7 Author(s): Wenqing Zhou, Arpita S. Pal, Alan Yi-Hui Hsu, Theodore Gurol, Xiaoguang Zhu, Sara E. Wirbisky-Hershberger, Jennifer L. Freeman, Andrea L. Kasinski, Qing Deng MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic inflammation (wound response) is augmented in miR-223-deficient zebrafish, due primarily to elevated activation of the canonical nuclear factor κB (NF-κB) pathway. NF-κB over-activation is restricted to t...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: Available online 23 February 2018 Source:Trends in Pharmacological Sciences Author(s): Eduardo N. Chini, Claudia C.S. Chini, Jair Machado Espindola Netto, Guilherme C. de Oliveira, Wim van Schooten Recent reports indicate that intracellular NAD levels decline in tissues during chronological aging, and that therapies aimed at increasing cellular NAD levels could have beneficial effects in many age-related diseases. The protein CD38 (cluster of differentiation 38) is a multifunctional enzyme that degrades NAD and modulates cellular NAD homeostasis. At the physiological level, CD38 has been implicated in th...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Group 2 innate lymphoid cells (ILC2s) are major producers of cytokines driving allergic asthma and elevated numbers of ILC2s have been detected in blood and sputum of asthma patients. Asthma susceptibility has a strong genetic component, but the underlying mechanisms and whether asthma genetics impact ILC2 biology remains unclear.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
This study aimed to determine its effect on telomere length and lung function in school‐aged children born preterm with BPD. MethodsWe examined 29 children with BPD, born preterm in Stockholm county 1998‐99, along with 28 children with allergic asthma born at term matched for age and gender. At 10 years of age, we measured relative telomere length (RTL) in blood by quantitative polymerase chain reaction, lung function by spirometry and inflammation by fractional exhaled nitric oxide and blood cytokines. ResultsRTL was not different in preterm born with BPD compared to term born children with asthma. The gender effect w...
Source: Acta Paediatrica - Category: Pediatrics Authors: Tags: Regular Article Source Type: research
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