Genomic Hallmarks of Thyroid Neoplasia.

Genomic Hallmarks of Thyroid Neoplasia.
Annu Rev Pathol. 2017 Oct 30;:
Authors: Giordano TJ
Abstract
The genomic landscape of thyroid cancers that are derived from follicular cells has been substantially elucidated through the coordinated application of high-throughput genomic technologies. Here, I review the common genetic alterations across the spectrum of thyroid neoplasia and present the resulting model of thyroid cancer initiation and progression. This model illustrates the striking correlation between tumor differentiation and overall somatic mutational burden, which also likely explains the highly variable clinical behavior and outcome of patients with thyroid cancers. These advances are yielding critical insights into thyroid cancer pathogenesis, which are being leveraged for the development of new diagnostic tools, prognostic and predictive biomarkers, and novel therapeutic approaches Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease Volume 13 is January 24, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 29083981 [PubMed - as supplied by publisher]

Source: Annual Review of Pathology - October 30, 2017 Category: Pathology Authors: Giordano TJ Tags: Annu Rev Pathol Source Type: research