Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy.
CONCLUSIONS: Overall, for women with a multiple pregnancy, the administration of progesterone (either IM or vaginal) does not appear to be associated with a reduction in risk of preterm birth or improved neonatal outcomes.Future research could focus on a comprehensive individual participant data meta-analysis including all of the available data relating to both IM and vaginal progesterone administration in women with a multiple pregnancy, before considering the need to conduct trials in subgroups of high-risk women (for example, women with a multiple pregnancy and a short cervical length identified on ultrasound).
PMID: 29086920 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Dodd JM, Grivell RM, OBrien CM, Dowswell T, Deussen AR Tags: Cochrane Database Syst Rev Source Type: research
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