An Investigation of the Single and Combined Phthalate Metabolite Effects on Human Chorionic Gonadotropin Expression in Placental Cells

Conclusions: Concentrations of MnBP, MBzP and MEHP similar to those found in the urine of pregnant women consistently altered hCG and PPARγ expression in primary placental cells. These findings provide evidence for the molecular basis by which phthalates may alter placental function, and they provide a preliminary mechanistic hypothesis for opposite responses by sex. https://doi.org/10.1289/EHP1539 Received: 23 December 2016 Revised: 6 September 2017 Accepted: 18 September 2017 Published: 31 October 2017 Address correspondence to J.J. Adibi, 130 Desoto Street, Parran Hall 5132, Pittsburgh, PA 15261 USA. Telephone: 412-624-1913. Email: adibij@pitt.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1539). The authors declare that they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (123 KB) Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Materia...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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ConclusionsThese voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse. However, diagnostic and treatment decisions should always be individualised based on patient-specific factors, such as disease extent and location, prior lines of therapy, comorbidities, and treatment preferences, together with current and emerging clinical evidence and logistic and economic constraints. Clinical trial enrolment for men with advanced prostate cancer should be strongly encouraged. Importantly, APCCC 2019...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Beginning in 2018, the Trump administration launched an aggressive effort to persuade states to pursue experiments under Section 1115 waivers, which allow states flexibility in the way they serve Medicaid beneficiaries. Many states have used these waivers to launch work-requirement programs that withhold coverage from most working-age, poor adults who fail to fulfill “community engagement” obligations. These obligations include documentation of nearly year-round work or other allowed activities, such as job training or volunteering for at least 20 hours per week. Some people may qualify for an exemption if they...
Source: The Commonwealth Fund: Blog - Category: International Medicine & Public Health Authors: Source Type: blogs
ConclusionsThis study showed that natalizumab dominated fingolimod with lower costs and higher QALYs in patients with high-activity RRMS. These results are consistent with previous published international literature.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 27 January 2020Source: Preventive MedicineAuthor(s): Louis Jacob, Lee Smith, Sarah E. Jackson, Jae Il Shin, Josep Maria Haro, Davy Vancampfort, Brendon Stubbs, Ai KoyanagiAbstractData on the association between informal caregiving and physical activity (PA) levels are scarce, especially from low- and middle-income countries (LMICs). Furthermore, previous research has yielded conflicting results. Thus, we investigated this association in adults from 38 LMICs. Data from the World Health Survey (WHS), a cross-sectional, predominantly nationally representative survey conducted in 2002–2...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 27 January 2020Source: Preventive MedicineAuthor(s): Nilofer S. Azad, Ira L. Leeds, Waruguru Wanjau, Eun J. Shin, William V. PadulaAbstractThe incidence of colorectal cancer (CRC) is increasing in patients under the age of 50. The purpose of this study was to assess the cost-utility of available screening modalities starting at 40 years in the general population compared to standard screening at 50 years old. A decision tree modeling average-risk of the CRC in the United States population was constructed for the cost per quality-adjusted life year (QALY) of the five most common and ef...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
ConclusionsThere is a need for better training of healthcare providers to be inclusive and reduce denial rates of their transgender and nonbinary patients. However, it is also clear that current rates of denial must be considered through a whole-person lens, considering the experience of concurrent oppressed identities and recognizing the increased risk those with multiple marginalized identities experience in being denied needed health care.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsExperiences of healthcare discrimination are not homogeneous across transgender help-seekers. Predictors of the latent classes indicated that transgender help-seekers holding an additional marginalized identity may be at higher risk for healthcare discrimination or care from providers with limited trans-competence. Targeted engagement and education interventions might improve these transgender help-seekers’ access to and connections with care.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionWhile previous studies have suggested that super-utilizers are a homogenous group of patients, the current study demonstrated a large degree of heterogeneity within super-utilizers. Variations in utilization patterns were associated with postoperative outcomes and subsequent health care costs.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
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Source: Research in Sports Medicine - Category: Sports Medicine Authors: Source Type: research
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