Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals.
In conclusion, although cecal intubation during colonoscopy was successful in all participants, it required a longer time in patients with acromegaly. Our results underscore the importance of and certain technical difficulties involved in colonoscopy procedures in patients with acromegaly, especially in older patients. PMID: 29081443 [PubMed - as supplied by publisher]
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02529G, CommunicationKun Fang, Shanchao Wu, Guoqiang Dong, Ying Wu, Shuqiang Chen, Jianhe Liu, Wei Wang, Chunquan Sheng The development of small molecules for cancer immunotherapy is highly challenging and indoleamine 2,3-dioxygenase 1 (IDO1) represents a promising target. Inspired by the synergistic effects between IDO1 inhibitors and traditional... The content of this RSS Feed (c) The Royal Society of Chemistry
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Jacob Thompson, the boy who got thousands of Christmas cards from charmed fans this fall, has died after a long battle with cancer.
Dalton Trans., 2017, Accepted Manuscript DOI: 10.1039/C7DT02616A, PaperWeijia Niu, I-Ting Teng, Xigao Chen, Weihong Tan, Adam Steven Veige A novel cationic NHC-Au(I) complex was synthesized and studied for its antitumor activity. For all the cell lines tested, cationic NHC-Au(I) complex 2 shows much higher cytotoxicity than its neutral... The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2017, Accepted Manuscript DOI: 10.1039/C7DT03229C, PaperKarolina Kowalczyk, Andrzej Blauz, Wojciech M. Ciszewski, Anna Wieczorek, Blazej Rychlik, Damian Plazuk A series of ferrocenyl and ruthenocenyl conjugates with colchicine bearing 1,2,3-triazole moiety were synthesized and their anticancer properties were evaluated. We found that the most potent metallocenyl derivativesRc4 and... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Soc. Rev., 2018, Advance Article DOI: 10.1039/C7CS00550D, Review ArticleSerge Mignani, Joao Rodrigues, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral Overview of the use of dendrimers in combination with encapsulated and conjugated natural products and analogues as anti-cancer agents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7CC08526E, CommunicationRavikumar Govindan, Meisam Bagheri, Deepak Kumar Saini, Harinath Chakrapani Thera/NO, a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) as well as a fluorescence signal is reported. Using cancer and primary cells, we show... The content of this RSS Feed (c) The Royal Society of Chemistry
Jacob Thompson battled neuroblastoma for four years, and people around the world pitched in to bring him joy in his final days
ConclusionThyroid micro-carcinomas are probably over-diagnosed among acromegalic patients. In regard to colon cancer, there is no sufficient data to suggest that colon cancer risk is higher in acromegaly compared to the general population.
Growth hormone (GH) excess in acromegaly is associated with increased precancerous colon polyps and soft tissue adenomas, whereas short-stature humans harboring an inactivating GH receptor mutation do not develop cancer. We show that locally expressed colon GH is abundant in conditions predisposing to colon cancer and in colon adenocarcinoma-associated stromal...