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Serious Mental Illness in Heavy Drinkers Is Associated with Poor Treatment Outcomes in Outpatients with Co-occurring Disorders

The objective of this study was to determine whether the interaction between type of serious mental illness (SMI) and pre-treatment drinking severity, assessed by ethyl glucuronide (EtG), predicts EtG-positive urine samples submitted during treatment in outpatients with co-occurring alcohol dependence and SMI. Seventy-nine participants were randomized to treatment-as-usual or treatment-as-usual and contingency management (CM) targeting alcohol abstinence. Generalized estimating equations were used to assess the interaction of pre-treatment drinking (heavy drinking or light drinking) and SMI diagnosis (major depression, bipolar, or schizophrenia-spectrum disorders) across a 12-week treatment period. In the overall sample, the interaction of drinking severity and SMI diagnosis (p = 0.006) was associated with alcohol abstinence. Exploratory analyses of the interaction term among participants randomized to CM (n = 40;p = 0.008) were associated with alcohol abstinence during CM. Type of SMI diagnosis was associated with treatment outcomes in individuals who engaged in heavy drinking, but not light drinking, prior to treatment.
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research

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Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
People have said this to me many times over the years. Here’s another Wheat Belly Basics conversation for newcomers or a refresher for the seasoned Wheat Belly follower. One of the reason that wheat and related grains are such effective causes of weight gain is that they contain a protein, gliadin, that, upon digestion, yields opioid peptides that bind to the opiate receptors of the human brain. These opioid peptides are responsible for generating addictive relationships with food, as well as behavioral and emotional effects. Stop eating grains and an opiate withdrawal syndrome ensues: nausea, headache, fatigue, depr...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle addiction appetite stimulant binge eating bulimia Detox eating disorders gluten gluten-free grain-free grains health opiates opioids Weight Loss wellness withdrawal Source Type: blogs
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Source: Shrink Rap - Category: Psychiatry Authors: Source Type: blogs
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: Addiction - Category: Addiction Authors: Tags: Research Report Source Type: research
I Am... Struggling with Anxiety: Create your own profile at Anxiety Social Net (anxietysocialnet.com) to connect with people dealing with everything from social anxiety to agoraphobia. Prefer to meet in person? Find a state-by-state list of support groups at the Anxiety and Depression Association of America’s website (adaa.org). Struggling with Depression or Bipolar Disorder: Locate an in-person or online group at the Depression and Bipolar Support Alliance site (dbsalliance.org). Struggling with Postpartum Depression: The Postpartum Progress site (postpartumprogress.com) lists support groups in nearly every state as...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Behavioral and Cognitive Neurology Child Adol Mental Disorders Cognition Current Issue Medical Issues Neurologic Systems and Symptoms Psychiatry Psychopharmacology Review Substance Use Disorders Cannabis dependence drug-related har Source Type: research
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