Serum eyes Rs 10,000 crore revenues by 2022, unveils new vaccines

The company is also developing vaccine and drug for dengue fever. It has commenced first phase of trials in Singapore and hopes to launch vaccine in 2020.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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Abstract Dengue virus (DENV) is a vector-borne human pathogen that usually causes dengue fever; however, sometime it leads to deadly complications such as dengue with warning signs (DWS+) and severe dengue (SD). Several studies have shown that fusion (Fu) and bc loop of DENV envelope domain II are highly conserved and consist some of the most dominant antigenic epitopes. Therefore, in this study, Fu and bc loops were joined together to develop a short recombinant protein as an alternative of whole DENV envelope protein, and its immunogenic potential as fusion peptide was estimated. For de novo designing of the ant...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Dengue virus (DENV, family Flaviviridae, genus Flavivirus) exists as four distinct serotypes. Generally, immunity after infection with one serotype is protective and lifelong, though exceptions have been described. However, secondary infection with a different serotype can result in more severe disease for a minority of patients. Host responses to the first DENV infection involve the development of both cross-reactive antibody and T cell responses, which, depending upon their precise balance, may mediate protection or enhance disease upon secondary infection with a different serotype. Abundant evidence now exists that resp...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The current lack of an effective vaccine to simultaneously protect against the four serotypes of DENV in seronegative individuals is a major unmet medical need. Further, the immunological basis for protective immunity in the setting of DENV infection or vaccination is not fully understood. Our team has developed a live attenuated tetravalent dengue virus vaccine that provides complete protection in a human model of dengue virus challenge. The goal of this study was to define, in the context of protective human vaccination, the quality of ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Future Virology, Ahead of Print.
Source: Future Virology - Category: Virology Authors: Source Type: research
Future Virology, Ahead of Print.
Source: Future Virology - Category: Virology Authors: Source Type: research
Abstract Dengue is the most important mosquito-borne viral infection in Sri Lanka causing an enormous social and economic burden in the country. In the absence of therapeutic drugs and the developed vaccines are under investigation, vector control is the best strategy to reduce the disease transmission. Therefore, the development of novel tools to control dengue vector mosquitoes has become the need of the hour. Novaluron is a recently developed Insect Growth Regulator (IGR) which inhibits chitin synthesis in immature stages of insects. The aim of the study was to identify the efficacy of a simple and cost-effecti...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract CYD-TDV is a live, attenuated, tetravalent dengue vaccine licensed in 21 countries. We undertook a post-hoc analysis of the long-term efficacy of CYD-TDV during the surveillance expansion phase (SEP) of two Phase III studies (CYD14 in the Asia-Pacific region; CYD15 in Latin America). The SEP included approximately Year 5 and the entire Year 6 of follow-up after the first study injection. Vaccine efficacy against symptomatic virologically-confirmed dengue (VCD) was assessed by participant age (any age, ≥9,
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Dengue virus (DENV) and Zika virus (ZIKV) are two mosquito-borne flaviviruses afflicting nearly half of the world population. Human infection by these viruses can either be asymptomatic or manifest as clinical diseases from mild to severe. Despite more cases are presented as self-limiting febrile illness, severe dengue disease can be manifested as hemorrhagic fever and hemorrhagic shock syndrome, and ZIKV infection has been linked to increased incidence of peripheral neuropathy Guillain-Barre syndrome and central neural disease such as microcephaly. The current prevention and treatment of these infectious diseases are eith...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 17 March 2020Source: The LancetAuthor(s): Vianney Tricou, Xavier Sáez-Llorens, Delia Yu, Luis Rivera, José Jimeno, Ana Cecilia Villarreal, Epiphany Dato, Onix Saldaña de Suman, Nathali Montenegro, Rodrigo DeAntonio, Sonia Mazara, Maria Vargas, Debbie Mendoza, Martina Rauscher, Manja Brose, Inge Lefevre, Suely Tuboi, Astrid Borkowski, Derek Wallace
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 17 March 2020Source: The LancetAuthor(s): Shibadas Biswal, Charissa Borja-Tabora, Luis Martinez Vargas, Hector Velásquez, Maria Theresa Alera, Victor Sierra, Edith Johana Rodriguez-Arenales, Delia Yu, V Pujitha Wickramasinghe, Edson Duarte Moreira, Asvini D Fernando, Dulanie Gunasekera, Pope Kosalaraksa, Felix Espinoza, Eduardo López-Medina, Lulu Bravo, Suely Tuboi, Yanee Hutagalung, Pedro Garbes, Ian Escudero
Source: The Lancet - Category: General Medicine Source Type: research
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