Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms

Pioglitazone (PIO), a thiazolidinediones drug, is a well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial. Thus it is important to investigate the effects of PIO on ather...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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(Oxford University Press USA) A new study soon to appear in the Faculty of Public Health's Journal of Public Health, published by Oxford University Press, suggests that air pollution and living in apartment buildings may be associated with an increased risk for dangerous conditions like heart disease, stroke, and type 2 diabetes. This paper is embargoed until midnight EST on June 25.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Contributors : Caiyan Zhang ; Yufeng ZhouSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensTo determine ceRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify ceRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research
Contributors : Caiyan Zhang ; Yufeng ZhouSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo determine miRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify miRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Purpose: To compare retinal pathology visualization in multispectral scanning laser ophthalmoscope imaging between the Spectralis and Optos devices. Methods: This retrospective cross-sectional study included 42 eyes from 30 patients with age-related macular degeneration (19 eyes), diabetic retinopathy (10 eyes), and epiretinal membrane (13 eyes). All patients underwent retinal imaging with a color fundus camera (broad-spectrum white light), the Spectralis HRA-2 system (3-color monochromatic lasers), and the Optos P200 system (2-color monochromatic lasers). The Optos image was cropped to a similar size as the Spectrali...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
In this study, we aimed to evaluate the efficacy and safety of intravitreal conbercept in patients with treatment-naive neovascular age-related macular degeneration in real-life setting. Methods: Three consecutive intravitreal injections of conbercept following a pro re nata protocol. The main outcomes were the changes of Early Treatment Diabetic Retinopathy Study best-corrected visual acuity and central retinal thickness between the baseline and the 12th month. Results: Mean best-corrected visual acuity was improved from 39.39 ± 24.91 letters at the baseline to 44.26 ± 22.89 letters at the final follow-up (P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Purpose: To investigate the natural history of Stargardt disease over a multiyear follow-up. Methods: We reviewed medical records of Stargardt disease patients, with clinical diagnosis of Stargardt disease at a single institution, which was also supported by molecular diagnosis. All patients underwent best-corrected visual acuity, fundus photography, optical coherence tomography, and full-field electroretinography. Results: The study cohort consisted of 157 Stargardt disease patients aged 30.4 ± 1.1 years. Longitudinal analysis (mean follow-up: 3 years) showed a significant worsening of best-corrected visual...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
ConclusionInfectious diseases are one of the most common factorsto hospitalize diabetic patients (27.7%), most of whom had diabetic foot infections, pneumonia, and soft tissue abscess.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
DiabetesMine reviews the new book " Blood Sugar in Check " that focuses on the mental and behavioral challenges of living with diabetes.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Publication date: September 2019Source: IJC Heart &Vasculature, Volume 24Author(s): Dhrubajyoti Bandyopadhyay, Arvind R. Devanabanda, Ramyashree Tummala, Sandipan Chakraborty, Adrija Hajra, Birendra Amgai, Tauseef Akhtar, Vardhmaan Jain, Raktim K. Ghosh
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Publication date: Available online 22 June 2019Source: Practical Radiation OncologyAuthor(s): Bindu V. Manyam, Chirag Shah, Neil M. Woody, Chandana A. Reddy, Michael A. Weller, Aditya Juloori, Mihir Naik, Stephanie Valente, Stephen Grobmyer, Paul Durand, Risal Djohan, Rahul D. TendulkarAbstractPurposeThe toxicity profile of breast reconstruction with post-mastectomy radiation therapy (PMRT) varies by technique and timing, and long-term data are limited. We compared rates of complications requiring re-operation (CRR) and reconstruction failure (RF) between immediate autologous reconstruction (I-AR), immediate tissue expande...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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