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Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms

Pioglitazone (PIO), a thiazolidinediones drug, is a well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial. Thus it is important to investigate the effects of PIO on ather...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Our weekly series of diabetes humor at DiabetesMine features a cartoon by Gareth Morgan in England.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go. XPO1 as a Novel Target for Therapies to Enhance Autophagy https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/ Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and un...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Thyroid nodules located in the upper pole of the gland were nearly five-times more likely to be malignant, suggesting possible anatomical or environmental influences.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
The 'trendy' diet of intermittent fasting may have adverse consequences on our metabolism, a new study warns. The diet may impair pancreatic function.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news
New study also suggests regimes that include intermittent fasting may cause other long-term health problemsFasting every other day to lose weight could have damaging side effects. That is the conclusion of a group of scientists speaking this weekend at the European Society of Endocrinology ’s annual meeting.Their findings suggest that fasting-based diets may impair the action of sugar-regulating hormone insulin, and lead to increased risk of diabetes. Care should be taken before starting such programmes, say researchers.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Diabetes Medical research Diets and dieting Life and style Society UK news Science Source Type: news
CONCLUSIONS: Our study showed that β-blockers during the ICU stay had no significant association with mortality or morbidity. However, β-blocker therapy was associated with increased mortality in non-diabetic patients. TRIAL REGISTRATION: ISRCTN07413772 ; (dated 13.07.2005). PMID: 29769112 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Retina Group of New York (RGONY) is proud to be a corporate Gold Sponsor of the Juvenile Diabetes Research Foundation (JDRF) Gala: One Night in Vegas on Friday, June 1, 2018 at the Crest Hollow...(PRWeb May 20, 2018)Read the full story at http://www.prweb.com/releases/2018/05/prweb15501431.htm
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news
In this study, a sensitive and efficient UPLC-MS/MS method for the quantification of canagliflozin and its metabolites in rat plasma was established and applied to pharmacokinetics in a type 2 diabetic rat model. We firstly investigated the pharmacokinetic changes of canagliflozin and its metabolites in type 2 diabetic rats in order to use canagliflozin more safely, reasonably and effectively. We identified three types of O-glucuronide metabolites (M5, M7 and M17), two kinds of oxidation metabolites (M8 and M9) and one oxidation and glucuronide metabolite (M16) using API 5600 triple-TOF-MS/MS. Following liquid–li...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion the Canadian-ACS is a valid accurate and simple prognostic risk score for short-term risk stratification in patients with ACS independent of hypertension, diabetes, smoking and troponin level.
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 19 May 2018 Source:Trends in Endocrinology & Metabolism Author(s): Jacqueline M. Ratter, Cees J. Tack, Mihai G. Netea, Rinke Stienstra The environment induces metabolic reprogramming of immune cells via specific signaling pathways. Recent studies have revealed that changes in cell metabolism affect key immune cell functions including cytokine production and migration. In diabetes, these functions are either insufficiently or excessively activated, translating into diabetes-associated complications, including increased susceptibility to infection and accelerated cardiovascular disease...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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