What Causes Hypernatremia?
Discussion Hypernatremia is a serum sodium of> 150 mEq/L. Basic causes are too much sodium or too little free water. If body weight is normal or increased, there is an increase in total body sodium without an appropriate increase in total body water. Normally when the serum sodium is increased there is transient hypertonicity of the plasma which causes the thirst center to be stimulated and antidiuretic hormone (ADH) to be released. The thirst center tells the person to drink more water and ADH causes the kidney to retain free water. This normally will allow the plasma tonicity to go back to normal. Treatment is by treating the underlying cause and appropriate free water administration. If the body weight is decreased, there is a lower amount of free water with a relative increase in total body salt. This occurs usually when there is hypovolemic dehydration such as diarrhea and inadequate free water intake. Normally ADH is produced to increase the free water but without adequate access to free water, the hypernatremia continues to be maintained. Treatment is by treating the underlying causes and appropriate free water administration. Severe diarrhea is one of the most common reasons for hypernatremia. Patients with hypernatremic dehydration have both lower total body sodium and free water, but there is relatively more free water loss than sodium loss. Patients then develop hypernatremia. Because the hypernatremic plasma is hypertonic, intracellular free water passes ...
We present an up-to-date systematic review of the current literature regarding the safety in artificial and natural sweeteners use as a means of weight loss or diabetes control.Expert opinion: Natural sweeteners have not been associated directly with NAFLD, and on the contrary, some, such as stevia, and trehalose, may have a protective effect. Rare sugars and polyols can be used safely and have significant benefits that include anti-oxidant effect and optimal glycemic control. Artificial sweeteners, due to their effect on NAFLD development and insulin resistance, are not indicated in patients with obesity or diabetes. Furt...
This study shows that ECE is a suitable dietary supplement candidate for the prevention or treatment of obesity or obesity-associated diseases, especially inflammation-related diseases. PMID: 32215011 [PubMed]
Conclusion: Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L. PMID: 32215009 [PubMed]
In this study, we aimed to evaluate the influence of insulin production on immune system after the onset of diabetes, and we showed that the duration of honeymoon period could be related to the onset of other autoimmune conditions. For this retrospective study, 159 children aged between 11 and 18 years with type 1 DM were eligible. They have been diagnosed diabetes at least 10 years ago and use exogenous insulin. Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience ...
Publication date: May 2020Source: Journal of Functional Foods, Volume 68Author(s): Pinggui Wang, Xiang Gao, Yan Li, Shanglong Wang, Jia Yu, Yuxi Wei
Spironolactone-furosemide combination therapy and acid-base disorders in liver cirrhosis patients . Int J Clin Pharmacol Ther. 2020 Mar 26;: Authors: Gottfriedová H, Lánská V, Jabor A, Čáslavská M, Špičák J, Horáčková M, Schück O Abstract OBJECTIVE: Respiratory alkalosis (RA) and dilutional hyperchloremic acidosis (DHA) are the most common acid-base balance (ABB) disorders in patients with liver cirrhosis. The aims of this study were to clarify whether RA develops in relation to DHA via respiratory compensation of metabolic acidos...
' These are not great signals, I think they're shocking, quite frankly,'one observer remarked.Medscape Medical News
CONCLUSION: A significant positive relationship was observed between sucrose in coffee and tea and the number of coronal or root caries lesions in community-dwelling elderly Japanese. PMID: 32212434 [PubMed - as supplied by publisher]
Publication date: Available online 27 March 2020Source: Molecular and Cellular EndocrinologyAuthor(s): Wenguang Chang, Hongge Fa, Dandan Xiao, Jianxun Wang
Publication date: Available online 27 March 2020Source: Molecular MetabolismAuthor(s): Lucia Russo, Lindsey Muir, Lynn Geletka, Jennifer Delproposto, Nicki Baker, Carmen Flesher, Robert O’Rourke, Carey N. Lumeng
More News: Brain | Brain Cancers | Burns | Cardiology | Children | Chloride | Cushing's Syndrome | Databases & Libraries | Diabetes | Diabetes Insipidus | Diets | Emergency Medicine | Endocrinology | Environmental Health | Heart | Hormones | Intensive Care | Laboratory Medicine | Learning | Men | Neurology | Nutrition | Pediatrics | Poisoning | Potassium | Rhabdomyolysis | Rotavirus | Skin | Sodium | Sodium Chloride | Sugar | Universities & Medical Training | Urology & Nephrology