Lyme disease is the most common tick-borne illness in the USA and Europe. Pathogens involved are Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in approximately 75% of patients. Neurological disease, including facial palsy, meningoencephalitis, aseptic meningitis and polyradiculopathy, occurs in 10 –15%. Cardiac disease, primarily manifest as heart block, is seen in 1–2%. Arthritis is seen as a late complication in about 30%.
This study integrated three expression profile datasets (GSE55235, GSE12021, and GSE55457) and one methylation profile dataset GSE111942 to elucidate the potential essential candidate genes and pathways in RA. Differentially expressed genes (DEGs) and differentially methylation genes (DMGs) were identified by R programming software, using Limma package and ChAMP package, respectively. DAVID performed gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs. Functional annotation and construction of a protein-protein interaction (PPI) network and the Molecular Complex Detect...
Publication date: Available online 11 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Sharon Tirosh-Levy, Yuval Gottlieb, Monica L. Mazuz, Igor Savisky, Amir Steinman
ConclusionsFemales with IA reported significantly higher rates of decline in general health, mood disturbance and increased disease activity during the period of social isolation. This was reflected in a trend towards greater levels of psychological distress.
Publication date: Available online 10 July 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Ricardo Becker Feijo, Juarez Cunha
CONCLUSION: Majority had noninfectious etiologies. Uveitis associated with juvenile idiopathic arthritis was rare. PMID: 32643984 [PubMed - as supplied by publisher]
Authors: Hatano K, Katsuse K, Suzuki T, Hashida H PMID: 32641655 [PubMed - as supplied by publisher]
Drug-induced Bullous Pemphigoid and Lupus Erythematosus Occurring under Anti-TNF-α and IL-6 Therapy in a Patient with Rheumatoid Arthritis. Intern Med. 2020 Jul 07;: Authors: Yoshikawa N, Matsubara E, Yamamoto M, Yamazaki H, Uehara M, Kamata M, Tanaka H Abstract A 65-year-old Japanese woman, who was diagnosed with rheumatoid arthritis and Sjögren's syndrome with various autoantibodies including anti-DNA antibody, developed bullous pemphigoid and hematological abnormalities like lupus erythematosus after adalimumab therapy. The discontinuation of adalimumab resolved those disorders but polyar...
ConclusionSlight changes in AUCinf, Cmax and CLR of metformin were observed when co-administered with peficitinib; however, these changes were considered not clinically relevant.
ConclusionThis is a rare case of a giant chronic calcified subdural empyema with no known preceding history of trauma or infection.
Publication date: Available online 10 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Alaa M. Al-Khafaji, Lesley Bell-Sakyi, Gerardo Fracasso, Lisa Luu, Dieter Heylen, Erik Matthysen, José A. Oteo, Ana M. Palomar