Lyme disease is the most common tick-borne illness in the USA and Europe. Pathogens involved are Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in approximately 75% of patients. Neurological disease, including facial palsy, meningoencephalitis, aseptic meningitis and polyradiculopathy, occurs in 10 –15%. Cardiac disease, primarily manifest as heart block, is seen in 1–2%. Arthritis is seen as a late complication in about 30%.
Publication date: June 2019Source: Ticks and Tick-borne Diseases, Volume 10, Issue 4Author(s):
CONCLUSIONS: No biochemical or significant histological liver toxicity for MTX was demonstrated when applying causality criteria for DILI. More studies with this methodology are necessary in order to improve the assessment of its frequency. PMID: 31105018 [PubMed - as supplied by publisher]
PMID: 31104048 [PubMed - in process]
Condition: Glenohumeral Arthritis Interventions: Other: Manuel Therapy plus Exercise Intervention; Other: Exercise Intervention Sponsor: Istanbul University Recruiting
Conditions: Tick Borne Encephalitis; Lyme Disease Interventions: Drug: Anti-borrelial antibiotic therapy; Other: No antibiotic. Sponsors: University Medical Centre Ljubljana; University of Ljubljana School of Medicine, Slovenia Completed
Abstract: Iatrogenic lymphoproliferative disorder (LPD) can develop in patients treated with immunosuppressive drugs for autoimmune or other inflammatory diseases. Here, we report a case of lymphomatoid granulomatosis of the skin that occurred as a methotrexate (MTX)-associated LPD. We also review the relevant literature. A 73-year-old woman presented to our department with an approximately 10-year history of MTX therapy for rheumatoid arthritis. Three months earlier, she noticed a small nodule in her right upper arm. It gradually enlarged, and the center began to decay. Grossly, the lesion was 40 × 40 mm in size w...
ConclusionART showed therapeutic effects on lupus-prone MRL/lpr mice by inhibiting the differentiation of Tfh cells as well as altering the activation status of Jak2-Stat3 signaling cascade.Graphical Abstract
Conclusion: 177Lu-DOTA-HA-PLGA(MTX) was prepared as a biocompatible polymeric PLGA nanoparticle conjugated to HA for specific targeting. The therapeutic nanosystem is based on bi-modal mechanisms using MTX as a disease-modifying antirheumatic drug (DMARD) and 177Lu as a radiotherapeutic component. The 177Lu-DOTA-HA-PLGA(MTX) nanoparticles showed properties suitable for radiosynovectomy and further specific targeted anti-rheumatic therapy.
Publication date: Available online 19 May 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Andreas Petersen, Maiken Worsøe Rosenstierne, Morten Rasmussen, Kurt Fuursted, Henrik Vedel Nielsen, Lee O’Brien Andersen, René Bødker, Anders FomsgaardAbstractIn 2008-2009 a tick-borne encephalitis virus (TBEV) micro-focus was detected in Northern Zealand, Denmark. No new cases of TBE with an epidemiological link to Northern Zealand has been reported since. Here we undertook to investigate Ixodus ricinus ticks from this endemic micro-focus in 2016 and 2017. In addition to TBEV, I. ricinus ticks may host...
Conclusions: Our overall data suggest that the generation of inflammatory monocytes is associated to the autoimmune/inflammatory response that mediates RA. These monocyte subsets, -which display specific and distinctive molecular signatures- might promote endothelial dysfunction and in turn, the progression of atherosclerosis through a finely regulated process driving CVD development in RA.