Differential Effect of Articaine on Sarcoendoplasmic Reticulum Calcium Adenosine Triphosphatase of Medial Pterygoid Muscle.

CONCLUSION: The differential inhibition of articaine on medial pterygoid SERCA isoforms is evident at concentrations lower than used in current dental practice (125 mM) and accounts for anesthetic myotoxicity. Muscle relaxation likely becomes impaired as a result of increased calcium levels in the myoplasm due to the decreased activity and calcium transport caused by the inhibition of SERCA. PMID: 29073670 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29073670?dopt=Abstract

Source: Journal of Orofacial Pain - October 29, 2017 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research