Up-regulation of α1-adrenoceptors in burn and keloid scars

A reciprocal relationship between α1-adrenoceptors (α1-AR) and cytokines may shape inflammation and wound healing. Activation of particular α1-AR subtypes boosts the migration and proliferation of fibroblasts in wounds [1–4], and triggers an increase in pro-inflammatory cytokine production in a range of cells [5–8]. Conversel y, in human THP-1 monocytes, interleukin-1β and tumour necrosis factor-α induce the expression of messenger RNA for the α1A-AR [9].

Source: Burns : Journal of the International Society for Burn Injuries - October 28, 2017 Category: Cosmetic Surgery Authors: Peter D. Drummond, Linda F. Dawson, Fiona M. Wood, Mark W. Fear Source Type: research