Revisiting interhemispheric imbalance in chronic stroke: a tDCS study

The immense burden of stroke-related disability has led to the development of noninvasive brain stimulation (NIBS) as a possible approach to augment neurorehabilitation of the paretic upper limb (Ackerley et al., 2010). Transcranial direct current stimulation (tDCS) is a polarity-dependent neuromodulatory technique that has demonstrated some benefit to motor function at the chronic stage (>6 months) post stroke, but effect sizes have varied (Jacobson et al., 2012; Kang et al., 2015).
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research

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Abstract Worldwide, millions of individuals suffer an ischemic stroke each year, causing major disability, especially in the elderly, where stroke is the number one cause of disability. However, to date, no effective therapy exists that targets the functional recovery after stroke. After necrosis, neuroinflammation is a common feature of the acute stroke and a major obstacle to tissue restoration. In the lesioned area, the dying neurons release chemotactic signals, such as fractalkine/CX3CL1, which evoke "eat-me" signals that are recognized by microglia expressing complement C3a receptor (C3aR), resultin...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Stroke is the leading cause of disability in adult life. Oropharyngeal dysphagia occurs in 65-90% of patients, and its identification in the acute phase of stroke can prevent complications. The aim of this study was to verify whether oropharyngeal dysphagia during stroke hospitalization is associated with functional capacity, as assessed by the modified Rankin Scale (mRs), and mortality 90 days after stroke.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Conclusions: The waist-to-height ratio was more closely related to the prevalence of stroke than body mass index, waist circumference, and weight-to-hip ratio among the study participants aged ≥ 40 years.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Studies showed heterogeneity in selecting outcomes and timings for assessment. There is evidence for assessing the evidence of orthosis-based gait rehabilitation after stroke through activity outcome measures, primarily the gait speed, recorded by non-wearable motion capture systems. A unified methodology considering wearable sensors for tracking baseline and follow-up measures is needed.Implications for rehabilitationThere is evidence on use activity outcome measures to assess the meaningful evidence-based practice of orthosis-based gait rehabilitation in post-stroke.Gait speed was the primary outcome measure...
Source: Disability and Rehabilitation. Assistive Technology. - Category: Rehabilitation Authors: Tags: Disabil Rehabil Assist Technol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The objectives were to map out the characteristics of assessing postural asymmetry; thereafter to synthesize on how postural asymmetry develops in time after a stroke and finally, to describe postural asymmetry and its relations.Material and methodsFollowing the PRISMA guidelines, a systematic search was performed using the databases MEDLINE, EMBASE, Cochrane library and PEDrO with the key words (Weight-Bearing Asymmetry OR Center of Pressure) AND (Stroke) for articles published through to November 2017.ResultsOne hundred and ninety-five articles were included and highlighted certain heterogeneity in the manner in which th...
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/ β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroi...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Conclusions: This pilot study demonstrated the feasibility of a metacognitive occupation-based telerehabilitation intervention and its potential benefits in activity performance, participation, and QoL for older adults coping with long-term disability following ABI.Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03048708.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
-- Stroke is the fifth leading cause of death and a leading cause of disability in the United States, says the American Stroke Association. The association mentions these warning signs: Face drooping. Is the person's smile uneven or lopsided? Arm...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Cardioembolic stroke is a major source of mortality and disability worldwide. The authors hypothesized that quantitative characterization of intracardiac blood stasis may be useful to determine cardioembolic risk in order to personalize anticoagulation therapy. The aim of this study was to assess the relationship between image-based metrics of blood stasis in the left ventricle and brain microembolism, a surrogate marker of cardiac embolism, in a controlled animal experimental model of acute myocardial infarction (AMI).
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Source Type: research
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