PD-1 deficiency protects experimental colitis via alteration of gut microbiota.

PD-1 deficiency protects experimental colitis via alteration of gut microbiota.
BMB Rep. 2017 Oct 25;:
Authors: Park SJ, Kim JH, Song MY, Sung YC, Lee SW, Park Y
Abstract
Programmed cell death-1 (PD-1) is a coinhibitory molecule and plays a pivotal role in immune regulation. Here, we demonstrate a role for PD-1 in pathogenesis of inflammatory bowel disease (IBD). Wild-type (WT) mice had severe wasting disease during experimentally induced colitis, while mice deficient for PD-1 (PD-1-/-) did not develop colon inflammation. Interestingly, PD-1-/- mice cohoused with WT mice became susceptible to colitis, suggesting that resistance of PD-1-/- mice to colitis is dependent on their gut microbiota. 16S rRNA gene-pyrosequencing analysis showed that PD-1-/- mice had altered composition of gut microbiota with significant reduction in Rikenellaceae family. These altered colon bacteria of PD-1-/- mice induced less amount of inflammatory mediators from colon epithelial cells, including interleukin (IL)-6, and inflammatory chemokines. Taken together, our study indicates that PD-1 expression is involved in the resistance to experimental colitis through altered bacterial communities of colon.
PMID: 29065967 [PubMed - as supplied by publisher]

Source: BMB Reports - October 25, 2017 Category: Biochemistry Authors: Park SJ, Kim JH, Song MY, Sung YC, Lee SW, Park Y Tags: BMB Rep Source Type: research