Pro-tumorigenic roles of TGF- β signaling during the early stages of liver tumorigenesis through upregulation of Snail.

Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail.
BMB Rep. 2017 Oct 25;:
Authors: Moon H, Han KH, Ro SW
Abstract
Many studies have focused on the tumor suppressive role of TGF-β signaling during the early stages of tumorigenesis by activating the target genes involved in cytostasis and apoptosis. We investigated the effects of TGF-β inhibition on early tumorigenesis in the liver, by employing diverse inhibitory methods. Strikingly, TGF-β inhibition consistently suppressed hepatic tumorigenesis that was induced either by activated RAS plus p53 downregulation or by the co-activation of RAS and TAZ signaling; this demonstrates the requirements for canonical TGF-β signaling in tumorigenesis. Moreover, we found that Snail is the target gene of the TGF-β signaling pathway that promotes hepatic carcinogenesis. The knockdown of Snail suppressed the early tumorigenesis in the liver, as did the TGF-β inhibition, while the ectopic expression of Snail restored tumorigenesis that was suppressed by the TGF-β inhibition. Our findings establish the oncogenic TGF-β-Smad-Snail signaling axis during the early tumorigenesis in the liver.
PMID: 29065973 [PubMed - as supplied by publisher]

Source: BMB Reports - October 25, 2017 Category: Biochemistry Authors: Moon H, Han KH, Ro SW Tags: BMB Rep Source Type: research