The Systemic Activation of Programmed Death 1-PD-L1 Axis Protects Systemic Lupus Erythematosus Model from Nephritis.

CONCLUSION: Our research demonstrated that the protective function of systemic activation of PD-1-PD-L1 axis with PD-L1-Ig attenuates the nephritis in SLE-prone mice, which facilitates us to understand the suppressive function of PD-1-PD-L1 axis in the pathogenesis and progress of the lupus nephritis, and to explore a possible effective therapeutic strategy to SLE. PMID: 29069649 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29069649?dopt=Abstract

Source: American Journal of Nephrology - October 26, 2017 Category: Urology & Nephrology Authors: Liao W, Zheng H, Wu S, Zhang Y, Wang W, Zhang Z, Zhou C, Wu H, Min J Tags: Am J Nephrol Source Type: research