Megakaryocyte and polyploidization

- MK endomitosis associates both a defect in cytokinesis and karyokinesis- A myosin II accumulation defect at the furrow induces the cytokinesis failure- MK polyploidization and maturation have close transcriptional regulation- MK ploidization is functionnally important for efficient platelet production- MK ploidy is altered in many pathologies, but associated with maturation defects

Source: Experimental Hematology - October 27, 2017 Category: Hematology Authors: Stefania Mazzi, Larissa Lordier, Najet Debili, Hana Raslova, William Vainchenker Tags: Review Source Type: research