Planetary ball milling and supercritical fluid technology as a way to enhance dissolution of bicalutamide

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Mateusz Kurek, Karolina Syrek, Krzysztof Chmiel, Marian Paluch, Renata Jachowicz Dissolution of bicalutamide processed with polyvinylpyrrolidone by either supercritical carbon dioxide or ball milling has been investigated. Various compositions as well as process parameters were used to obtain binary systems of the drug with the carrier. Thermal analysis and powder X-ray diffractometry confirmed amorphization of bicalutamide mechanically activated by ball milling and the decrease in crystallinity of the supercritical carbon dioxide-treated drug. Both methods led to reduction of particles size what was confirmed by scanning electron microscopy and laser diffraction measurements. Moreover, the effect of micronisation was found to depend on the parameters of applied process. Fourier transform infrared spectroscopy revealed the appearance of intermolecular interactions between drug and carrier molecules that play an important role in the stabilization of amorphous form of the active compound. Changes in crystal structure combined with reduced size of particles of bicalutamide dispersed within polymer matrix were found to improve dissolution of bicalutamide by 4 to 10-fold in comparison to untreated drug. It is of particular importance as poor dissolution profiles are considered to be the major limitation in bi...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

Related Links:

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, and its realm of basic mechanisms and predisposing factors is similarly wide. The Journal of Investigative Dermatology (JID) has recently published a surprisingly numerous collection of articles, comments, and reviews that scan the universe of basic information about AD. This review is directed toward using the JID Collections to provide a background and melding of research focuses in the current setting. This online commentary will attempt to consolidate and interweave some of the featured studies that have emerged.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
CONCLUSION: It is important to be aware of the increased incidence of CHF in some immigrant groups, especially from countries and areas where the immigrants have been refugees, in order to enable for a timely diagnosis, treatment of and prevention of CHF and its debilitating complications. PMID: 30445882 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
CONCLUSION: 3DRA allows for detailed per-procedural evaluation of right atrial anatomy and revealed a great variability in Koch's triangle and CTI dimensions and morphology. Right atrial enlargement as measured by RAVI was an independent predictor for AF occurrence during follow-up. PMID: 30445881 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
CONCLUSION: A simple objective decision rule (CORE) identified one-third of all patients as having a very low 30-day risk of MACE. These patients may potentially be discharged without additional investigations for acute coronary syndrome. PMID: 30444442 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Authors: Zhengguang L, Jie H, Yong Z, Jiaojiao C, Xingqi W, Xiaoqin C Abstract OBJECTIVE: The purpose of this study is to research the mechanism of percutaneous penetration of Ibuprofen (IBU) nanoemulsion. METHOD: Transdermal penetration mechanism of IBU n anoemulsion was investigated by Fourier Transform infra-Red spectral analysis (FTIR), Differential Scanning Calorimeter thermogram (DSC), activation energy(Ea) measurement The in vivo skin penetration test of rats was carried out using Rhodamine B nanoemulsion to simulate the process of drug penetration into the skin, and the frozen section of the skin was ob...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
In conclusion, this work predicted the binding mode and quantitatively characterized the protein–peptide interface, which will aid in the discovery of novel drugs targeting the GluN2B-CT1290-1310 and DAPK1 interface.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractBackgroundSkeletal maxillary expander (MSE) is one of the more recent expander designs being utilized for skeletal expansion by splitting the midpalatal sutures applying forces through palatal micro-implants. Its effects on the soft tissue remain a question asked by both patients and clinicians. The aim of this study was to analyze and quantify soft tissue facial changes induced by MSE.Methods3D facial images (3dMD) were used to capture face scans of 25 patients generating 3D soft tissue meshes before expansion (T0), right after expansion (T1), and 1  year in retention (T2). MATLAB was then used, utilizing non...
Source: Progress in Orthodontics - Category: Dentistry Source Type: research
ConclusionIntegrating cases of sternoclavicular joint ORN promotes awareness of atypical laryngopharyngeal radiation complications, elucidates contributing factors, educates physicians on presentation and management, and provides a platform for prospective investigation.Level of Evidence4.Laryngoscope, 2018
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
Publication date: Available online 17 November 2018Source: Journal of Materials Science &TechnologyAuthor(s): Bin Liu, Yuchen Liu, Changhua Zhu, Huimin Xiang, Hongfei Chen, Luchao Sun, Yanfeng Gao, Yanchun ZhouAbstractThermal barrier coating (TBC) materials play important roles in gas turbine engines to protect the Ni-based super-alloys from the high temperature airflow damage. High melting point, ultra-low thermal conductivity, large thermal expansion coefficient, excellent damage tolerance and moderate mechanical properties are the main requirements of promising TBC materials. In order to improve the efficiency of je...
Source: Journal of Materials Science and Technology - Category: Materials Science Source Type: research
In this study, resveratrol was successfully encapsulated using zein-chitosan complex coacervation. The encapsulation efficiency was markedly improved (51.4%) after chitosan coating at 1:2.5 zein/chitosan ratio, compared with 38.6% using native zein. Analysis of multi-model frequency ultrasound treatment effects on resveratrol encapsulation using zein-chitosan complex coacervation showed that 28/40 kHz dual-frequency ultrasound led to the highest encapsulation efficiency (65.2%; 31.9% increase) and loading capacity (5.9%; 31.1% increase) of resveratrol, followed by multi-frequency ultrasound at 20/28/40 kHz (17.8% encapsula...
Source: Food Chemistry - Category: Food Science Source Type: research
More News: Drugs & Pharmacology | PET Scan