Development and characterization of mucoadhesive buccal gels containing lipid nanoparticles of ibuprofen

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Ana Camila Marques, Ana Isabel Rocha, Paula Leal, Marilene Estanqueiro, José Manuel Sousa Lobo The lipid nanoparticles, namely Nanostructured Lipid Carriers (NLC), as drug delivery systems have been investigated for several years. One of the delivery routes for which these carriers can be applied is buccal administration. However, the liquid dispersions of lipid nanoparticles can be rapidly removed from oral cavity by saliva. Thus, the development of a system that allows increased retention time on the mucosa is necessary. For this reason, the development of mucoadhesive preparations for buccal administration of lipid nanoparticles becomes important. Hydrogels prepared with mucoadhesive polymers (Carbopol® 980 and polycarbophil) constitute a promising option. The aim of this work was to develop mucoadhesive buccal hydrogels with NLC, using ibuprofen as a model drug. The obtained results showed that the developed NLC dispersions presented particles in the nanometric size range, with low polydispersity index values and efficient ability for the entrapment of the model drug. Moreover, the incorporation of NLC in hydrogels of mucoadhesive polymers resulted in preparations with desirable rheological features as well as texture (firmness and adhesiveness) and mucoadhesive properties, which could benefit the therapeutic efficacy, by increasing the residence ti...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 20 April 2019Source: Advances in PediatricsAuthor(s): Megan M. Langille, Alice Rutatangwa, Carla Francisco
Source: Advances in Pediatrics - Category: Pediatrics Source Type: research
Publication date: Available online 20 April 2019Source: Advances in PediatricsAuthor(s): Melissa Harada, Nelly Amariglio, Hope Wills, Irene Koolwijk
Source: Advances in Pediatrics - Category: Pediatrics Source Type: research
CONCLUSIONS: The assessment of pain, sedation and delirium is demonstrated, and low percentages of agitation and delirium achieved. We observed a high percentage of patients with pain, and moderate use of PC. We should generalise the use of protocols to assess, prevent and treat pain and delirium by appropriately managing analgesia, sedation, and individual and well-considered use of PC. (ClinicalTrials.gov Identifier: NCT03773874). PMID: 31003871 [PubMed - as supplied by publisher]
Source: Enfermeria Intensiva - Category: Nursing Tags: Enferm Intensiva Source Type: research
BENEFITS OF SPECIALIZED CARE IN A SPECIFIC FRAILTY UNIT. Enferm Intensiva. 2019 Apr - Jun;30(2):45-46 Authors: Pastor AC, Fuentes AM, Garcia PP, Santos CF, Peromingo JM, Martín RB PMID: 31003617 [PubMed - in process]
Source: Enfermeria Intensiva - Category: Nursing Tags: Enferm Intensiva Source Type: research
ConclusionPD-L1 expression is frequent in esophagogastric adenocarcinoma and - when combined with dense CD8 infiltration – PD-L1 negativity correlates with prolonged overall survival.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: April 2019Source: Journal of Comparative Pathology, Volume 168Author(s): S. Kleinschmidt, S. Mammen, C. PuffSummaryThe present report describes a case of a post-traumatic ocular leiomyosarcoma in a calf (Bos primigenius taurus) including clinical, histopathological and immunohistochemical features. Following a traumatic episode, the animal developed opacification of the lens and shrinkage of the eye. Subsequently, the ocular lesion increased in size over a period of 6 weeks and reached up to 16 cm in diameter with infiltration into the cranium. At necropsy examination, the kidneys, liver and spleen e...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
We report a case of 2 years old female child presented to emergency with history of fall from stairs on an outstretched hand. Radiograph showed a metaphyseal spike in the proximal radius which prompted us to think of a radial neck fracture. Since the radial head was not ossified, the amount of displacement and angulation was not exactly quantifiable on radiographs only. Hence an arthrogram was planned. Intra operative use of radio opaque dye injection into elbow joint delineates the radial head and capitellum. It helps in identifying the fracture morphology and will also assist in reduction. We reduce radial head by K wire...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Publication date: Available online 20 April 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Junko Hori, Takefumi Yamaguchi, Hiroshi Keino, Pedram Hamrah, Kazuichi MaruyamaAbstractCorneal transplantation is the most successful solid organ transplantation performed in humans. The extraordinary success of orthotopic corneal allografts, in both humans and experimental animals, is related to the phenomenon of “immune privilege”. Inflammation is self-regulated to preserve ocular functions because the eye has immune privilege. At present, three major mechanisms are considered to provide immune privilege in ...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Publication date: May 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 5Author(s):
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Tuoping Li, Xuejiao Chen, Zhu Huang, Wanying Xie, Chaonan Tong, Ruiwen Bao, Xiao Sun, Wenjie Li, Suhong LiAbstractEffects of pectin oligosaccharide (POS) derived from hawthorn fruit on the nuclear factor kappa-B (NF-κB) pathway-related factors were investigated in the liver of mice fed a high-fat diet. The results showed that POS significantly reduced the total liver fat content and the levels of hepatic pro-inflammatory factors tumor necrosis factor (TNF)-α and interleukin-6 (IL-6), while increased the level of interleukin-10 (...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
More News: Drugs & Pharmacology | Ibuprofen | Nanotechnology