Microstructure evaluation of dermally applicable liquid crystals as a function of water content and temperature: Can electron paramagnetic resonance provide complementary data?

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Mirjam Gosenca Matjaž, Janez Mravljak, Marija Bešter Rogač, Marjeta Šentjurc, Mirjana Gašperlin, Alenka Zvonar Pobirk Insight into the microstructure of lyotropic liquid crystals (LCs) is of crucial importance for development of novel dermal delivery systems. Our aim was to evaluate the phase behaviour of dermally applicable LCs composed of isopropyl myristate/Tween 80/lecithin/water, along the dilution line, where phase transitions are predominantly driven by increased water content. Additionally, identification of LC temperature dependence is of great importance for skin application. Selected LCs were evaluated using electron paramagnetic resonance (EPR) plus conventionally used methods of polarization microscopy, small-angle X-ray scattering, differential scanning calorimetry, and rheological measurements. Depending on water content, LCs formed diverse microstructures, from (pseudo)hexagonal (LC1) and lamellar (LC2-LC7) liquid crystalline phases that possibly co-exist with rod-like micelles (LC4-LC7), to a transitional micellar phase (LC8). Furthermore, the LCs microstructure remained unaltered within the tested temperature range. EPR was shown to detect microstructural transitions of LCs and to provide complementary data to other techniques. These data thus confirm the applicability of EPR as a complementary technique for better understa...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 24 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Brooke Liang, Sara S. Lange, L. Stewart Massad, Rebecca Dick, Kathryn A. Mills, Andrea R. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Katherine C. Fuh, David G. Mutch, Matthew A. Powell, Lindsay M. KurokiAbstractObjectiveTo assess the renal outcomes of gynecologic oncology patients who present with hydronephrosis and acute kidney injury (AKI), have
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
ConclusionPET-scan and tDCS seems to be promising tools for the evaluation and treatment of PNES in clinical practice, and may have a specific role on dissociative symptoms.
Source: Brain Stimulation - Category: Neurology Source Type: research
PENTAX Medical, a global medical technology developer originally founded in Japan, provides the PlasmaTYPHOON Endoscope Drying and Storage Device through its controlling interest in PlasmaBiotics, a company based in France. The system aims to signifi...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive GI Public Health Source Type: blogs
We present a case of a male with 6 months of diarrhea and malaise who was found to have significant kidney injury and hypokalemia requiring admission to the medical intensive care unit. Subsequent laboratory evaluation while admitted eventually showed a low stool osmotic gap ( –11 mOsm/kg) consistent with secretory diarrhea, in addition to significantly elevated VIP levels at 940 pg/mL (normal #x3c;75). Cross-sectional imaging with functional Gallium-68 dotatate PET-CT confirmed metastatic functional neuroendocrine tumor indicative of a VIPoma. Pathology on subsequent m etastatic liver lesion aspiration was consisten...
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionThe follow-up data in this study showed good outcomes with reliable results for PSI made of PEEK in the maxillofacial region.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionThis study identified no significant associations of allelic or genotypic SNPs with the susceptibility of epilepsy and medication response with an exception of rs2304016 and rs2499697 SNPs that were associated with the generalized type of epilepsy among Jordanian population. Further studies are required in different populations to confirm our results and identify genetic factors that involved in susceptibility and treatment response.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
We present a new in vitro prediction method for acute inhalation toxicity using the Calu-3 epithelial cytotoxicity assay applicable for water-soluble inhalable chemicals.MethodTo confirm the characteristics of the optimal Calu-3 epithelium, tight-junction formation, morphology, and mucus secretion were verified using scanning electron microscopy, transepithelial electrical resistance analysis, and immunofluorescence after growth in an air-liquid interface (ALI). Sixty chemicals, including 38 positive and 22 negative for acute inhalation toxicity, were selected from the European Chemical Agency chemical database. The cell v...
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
Authors: Saraiva S, Cortez-Pinto J, Barosa R, Castela J, Moleiro J, Rosa I, da Siva JP, Dias Pereira A Abstract BACKGROUND: Fatigue is a common symptom reported in inflammatory bowel disease (IBD) patients. It can be severe and modify the self-perception of disease. OBJECTIVE: To evaluate the contribution of clinical and demographic factors to the level of fatigue in IBD patients. METHODS: Patients consecutively observed in an outpatient IBD clinic during a 9-month period were studied. Demographic and clinical data were collected. Fatigue was assessed using the Functional Assessment of Chronic Illness Thera...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Authors: Rindom Krogsgaard L, Kristian Munck L, Bytzer P, Wildt S Abstract BACKGROUND AND AIM: Microscopic colitis (MC) is an inflammatory disease of the bowel, hypothetically induced by an immunologic response to a luminal microbial agent. We aimed to characterize the microbiome composition in MC and subtypes collagenous colitis (CC) and lymphocytic colitis (LC) and to identify a possible microbial effect of treatment. METHOD: Stool samples were collected from MC patients prior to treatment, at 8 weeks (during treatment) and at 16 weeks (after treatment), and from healthy controls, not receiving trea...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
CONCLUSIONS: Although based on a small cohort, our results confirm that patients with CVID and villous atrophy are burdened by a very high mortality mainly due to onco-immunological disorders and infections. Strict follow-up is required in these patients. PMID: 31006294 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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