Computational and experimental model of transdermal iontophorethic drug delivery system
In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst–Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery. Graphical abstract
Endo International Plc on Monday said it would stay its lawsuit against the U.S. Food And Drug Administration until the end of the year after the FDA made new commitments on the regulation surrounding the active ingredient in its blood pressure medicine Vasostrict.
The U.S. Food and Drug Administration on Monday approved Boston Scientific Corp's drug-coated stent Eluvia to treat narrowed arteries in the leg.
PANCREATIC cancer symptoms are ’t usually present in the early stages of the disease, making it difficult to diagnose. However, symptoms may appear as the disease progresses, such as this common everyday problem.
Researchers from the University of Bath examine whether there is any evidence behind increasingly popular hangover medication, as well as if drinking lots of water is enough.
Pastor Francis Gichuru Gachieki from Nairobi in Kenya, has a condition called prolactinoma caused by a non-cancerous brain tumour which has affected his hormone balance.
Lexi Chambers, of Exeter, is trying to raise £10,000 to have her leg amputated as she believes it would give her her life back. The NHS has yet to decide if it will pay.
VITAMIN B12 deficiency symptoms can vary widely, from feeling extremely tired to losing weight. Difficulty doing this daily function or noticing changes related to it could also be a symptom of a lack of B12.
China said on Monday it has confirmed a new outbreak of African swine fever in the Inner Mongolia Autonomous Region of northern China, as authorities struggle to contain the highly contagious disease.
Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.
Lessons from Jane Brody ’ s brother: Being trim and athletic doesn ’ t always mean your coronary arteries are in great shape.