Analysis of pellet coating uniformity using a computer scanner

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Rok Šibanc, Matevž Luštrik, Rok Dreu A fast method for pellet coating uniformity analysis, using a commercial computer scanner was developed. The analysis of the individual particle coating thicknesses was based on using a transparent orange colored coating layer deposited on white pellet cores. Besides the analysis of the coating thickness the information of pellet size and shape was obtained as well. Particle size dependent coating thickness and particle size independent coating variability was calculated by combining the information of coating thickness and pellet size. Decoupling coating thickness variation sources is unique to presented method. For each coating experiment around 10000 pellets were analyzed, giving results with a high statistical confidence. Proposed method was employed for the performance evaluation of classical Wurster and swirl enhanced Wurster coater operated at different gap settings and air flow rates. Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 17 September 2018Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Wenjuan Li, Yuxiang Cao, Xingrong Xuan, Zhiyi Shi, Ye Zhang, Jiamin Liu, Zhiyi Bai, Yuanshuai Fu, Minglin WuAbstractTo examine Ca2+ absorption and transportation in the freshwater pearl oyster, Hyriopsis cumingii Lea, we studied the effects of different levels of either extracellular Ca2+ or 1,25(OH)2D3 on extracellular Ca2+ flux and intracellular Ca2+ concentrations in mantle cells using the non-invasive micro-test technique and laser scanning confocal microscopy. The inn...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 17 September 2018Source: Journal of Environmental Chemical EngineeringAuthor(s): Yuchi Wan, Jun Chen, Jing Zhan, Yalin MaAbstractMesoporous NiCo2O4 fibers were synthesized by the coordination co-precipitation-decomposition method using ammonia as morphology-controller. The as-prepared NiCo2O4 powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-vis absorption spectra and photoluminescence (PL) analysis. The as-prepared NiCo2O4 materials showed typical intertwined porous nanofibrous structures with specific su...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
In this study, polypropylene (PP)/cyclic olefin copolymer (COC) blends were processed in a co-rotating twin screw extruder by melt processing technique. PP/COC blends were prepared without compatibilizer as COC is expected to be compatible with polypropylene due to its olefinic behaviour. Effects of COC blending with PP on mechanical, dynamic mechanical, rheological and morphological behaviour were investigated thoroughly. An increasing fraction of stiffened COC in the PP/COC blends is responsible for the enhancement of tensile strength and modulus, flexural strength and modulus and of a decrease in the elongation at break...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Dessa is a singer and writer from Minneapolis who spent years trying to fall out of love and get over her ex. Nothing seemed to help — until she visited a research lab for a brain scan.(Image credit: Adam Cole/NPR's Skunk Bear)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Study Design. Retrospective image-based analysis. Objective. To measure endplate three-dimensional (3D) geometry, endplate changes in vivo and to investigate correlations between disc degeneration and endplate 3D geometry dependent on symptoms of low back pain (LBP). Summary of Background Data. It has been hypothesized that alteration of load transmission from the nucleus pulposus to the annulus fibrosus affects vertebral endplate geometry. Methods. 3D surface models of inferior/superior lumbar endplates were created from computed tomography scans of n = 92 volunteers with and without LBP. Disc degeneration ...
Source: Spine - Category: Orthopaedics Tags: Biomechanics Source Type: research
In life, timing is everything. With sodium fluoride (NaF) PET, interpreting...Read more on AuntMinnie.comRelated Reading: Can deep learning monitor lesions on F-18 NaF PET/CT? CMS again declines coverage for NaF-PET scans ACC: PET/CT calcium scans could foretell cardiac events NaF-PET/CT beats scintigraphy, SPECT/CT for bone metastases
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01490F, MinireviewFraser P. Filice, Zhifeng Ding Single live cell analysis methods provide information on the characteristics of idividual cells, yielding not only bulk population averages but also their heterogeneity. Scanning electrochemical microscopy (SECM) offers single live... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
AbstractPurposeTo compare the diagnostic capability of three-dimensional (3D) neuro-retinal rim thickness (NRR) with existing optic nerve head and retinal nerve fiber layer (RNFL) scan parameters using high-definition optical coherence tomography (HD-OCT).DesignRetrospective study.MethodsBased on the mean deviation (MD) of the Humphrey Field Analyzer (HFA), the 152 subjects were categorized into mild (MD>  − 6 dB, 100), moderate (MD − 6 to − 12 dB, 26), and severe (MD
Source: Japanese Journal of Ophthalmology - Category: Opthalmology Source Type: research
ConclusionCT-guided biopsy is effective for the preoperative diagnosis of spinal IOS. Total resection is the optimal treatment for IOS, whereas subtotal resection could be an alternative choice for high-risk cases.Graphical abstractThese slides can be retrieved under electronic supplementary material.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
ConclusionsIntraureteral and intraurinary diversion ICG may be utilized as a real-time contrast agent during robotic ureteroenteric reimplantation to assist with identification of the strictured ureter and urinary diversion, and delineation of the ureteroenteric stricture margins. Despite this, RUER remains a technically difficult and morbid procedure.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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