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Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news

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Publication date: Available online 10 November 2018Source: Advances in Virus ResearchAuthor(s): Eugene V. Koonin, Natalya YutinAbstractThe Nucleocytoplasmic Large DNA Viruses (NCLDV) of eukaryotes (proposed order “Megavirales”) comprise an expansive group of eukaryotic viruses that consists of the families Poxviridae, Asfarviridae, Iridoviridae, Ascoviridae, Phycodnaviridae, Marseilleviridae, Pithoviridae, and Mimiviridae, as well as Pandoraviruses, Molliviruses, and Faustoviruses that so far remain unaccounted by the official virus taxonomy. All these viruses have double-stranded DNA genomes that range in size...
Source: Advances in Virus Research - Category: Virology Source Type: research
In this study, we compared the GH nadir during OGTT in patients evaluated for acromegaly in the presence and absence of AGM.MethodsThis is a retrospective cohort study of patients with acromegaly (G1,n = 40) and a group in whom acromegaly was not confirmed (G2,n = 53) who had OGTT-GH suppression test during 2000–2012, using a monoclonal GH immunoenzymatic assay. The patients were categorized as having normal glucose metabolism (NGM) or AGM. GH nadir during OGTT in each group were compared.ResultsIn G1 and G2, 17 and 19 patients had AGM, respectively. Among 17 patients with diabetes, median...
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionTreatments used to normalize IGF-I levels in patients with acromegaly could have differential effects on cardiovascular risk factors and metabolic parameters.
Source: Endocrine - Category: Endocrinology Source Type: research
Abstract Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) plays a key role in the secretion of growth hormone (GH). In this review, we summarize the current state of knowledge regarding the physiology and molecular machinery of VGCCs in pituitary somatotrophs. We next discuss the possible involvement of Ca2+ channelopathies in pituitary disease and the potential usage of Ca2+ channel blockers in the treatment of pituitary disease. Various types of VGCCs exist in pituitary cells. However, since L-type Ca2+ channels (LTCCs) contribute the major component to Ca2+ influx in somatotrophs, lactotrophs and cortico...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Authors: Katsumata N Abstract Determination of serum levels of GH and IGF-I is crucial for the diagnosis and treatment of GH deficiency and disorders related to GH excess such as acromegaly and pituitary gigantism. However, significant discrepancies in measured GH values among the methods were observed around the world. In Japan, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science standardized GH values measured with various commercially available GH assay kits by creating formulas to adjust them to their averages. The committee also established reference values for IGF-I in Japa...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Prof Márta Korbonits gave the Lady Estelle Wolfson lecture in translational medicine at the Royal College of Physicians on the 24 October 2018, during the Acute and General Medicine Conference. The lectureship is awarded to applicants who have made a contribution to translational research or medicine that has demonstrable benefit to patients.Prof Korbonits was selected for her translational work on conditions associated with growth hormone excess, starting in childhood and producing pituitary gigantism, and her talk was entitled,“Legends, genetics and molecular biology”.
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
AbstractPurposeTo determine whether pre-surgical medical treatment (PSMT) using long-acting Somatostatin analogues in acromegaly may improve long-term surgical outcome and to determine decision making criteria.MethodsThis retrospective study included 110 consecutive patients newly diagnosed with acromegaly, who underwent surgery in a reference center (Marseille, France). The mean long-term follow-up period was 51.4  ± 36.5 (median 39.4) months. Sixty-four patients received PSMT during 3–18 (median 5) months before pituitary surgery. Remission was defined at early (3 months) evaluation and at last...
Source: Pituitary - Category: Endocrinology Source Type: research
The causes and consequences of pituitary gigantism, Published online: 25 October 2018; doi:10.1038/s41574-018-0114-1Pituitary gigantism is a rare growth disorder caused by excessive release of growth hormone and insulin-like growth factor 1. This Review discusses the diagnosis, genetic causes and clinical management of pituitary gigantism.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research
ConclusionThis is a rare case of MAS. Gigantism within the context of a pituitary calcification raises special diagnostic and therapeutic challenges. The cause of the excessive secretion of GH in MAS is not well understood concluding that it seems to be a different etiology of patients with Acromegaly and Gigantism in non-MAS patients.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusion: It is difficult to diagnose coexisting RCC preoperatively due to variable size, position and signal intensity. However when a nonenhancing cyst is incidentally detected by MRI in a patient with pituitary adenoma, the possibility of a coexisting RCC should be considered. PMID: 30341868 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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