P261 A 15-year journey: from relapsing polychondritis to IGG4-related disease

Relapsing polychondritis is a rare disease of unknown etiology characterized by recurrent inflammation involving multiple cartilaginous structures throughout the body. A handful of reports have suggested a possible connection of IgG4-related disease with the pathogenesis of relapsing polychondritis. IgG4-related disease is also an uncommon immune-mediated systemic inflammation disorder that can involve the pancreas, kidneys, salivary glands, aorta, orbits, and skin, among others. The hallmark of this disease is a lymphoplasmacytic infiltrate enriched in IgG4-positive plasma cells and fibrosis in involved tissues.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research