Uganda:Marburg Patient Who Went Into Hiding Dies

[Monitor] The Marburg patient who had gone into hiding has died.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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ConclusionThis outbreak of MVD occurred as a family cluster with no additional transmission outside of the four related cases. Rapid case detection, prompt laboratory testing at the Uganda National VHF Reference Laboratory and presence of pre-trained, well-prepared national and district rapid response teams facilitated the containment and control of this outbreak within one month, preventing nationwide and global transmission of the disease.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Du Xiangguo Qiu Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication. To generate anti-filovirus monoclonal antibodies (mAbs) against the NP, mice were immunized with peptides known as B-cell epitopes corresponding to different filovirus NPs, and hybridomas were screened using FLAG-tagged filovirus NP constructs. Numerous mAbs were identified, isotyped, and characterized. The anti-NP mAbs demonstrated different ranges of binding affinities to various filovirus NPs. Most of the clones specifically ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ing Bats are known to harbor and transmit many emerging and re-emerging viruses, many of which are extremely pathogenic in humans but do not cause overt pathology in their bat reservoir hosts: henipaviruses (Nipah and Hendra), filoviruses (Ebola and Marburg), and coronaviruses (SARS-CoV and MERS-CoV). Direct transmission cycles are often implicated in these outbreaks, with virus shed in bat feces, urine, and saliva. An additional mode of virus transmission between bats and humans requiring further exploration is the spread of disease via arthropod vectors. Despite the shared ecological niches that bats fill with many h...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Jonathan S. Towner Egyptian rousette bats (Rousettus aegyptiacus) are natural reservoir hosts of Marburg virus (MARV), and Ravn virus (RAVV; collectively called marburgviruses) and have been linked to human cases of Marburg virus disease (MVD). We investigated the clinical and pathologic effects of experimental MARV infection in Egyptian rousettes through a serial euthanasia study and found clear evidence of mild but transient disease. Three groups of nine, captive-born, juvenile male bats were inoculated subcutaneously with 10,000 TCID50 of Marburg virus strain Uganda 371Bat2007, a minimally passaged virus original...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Marceline Côté Filoviruses, such as Ebola virus (EBOV) and Marburg virus, are causative agents of unpredictable outbreaks of severe hemorrhagic fevers in humans and non-human primates. For infection, filoviral particles need to be internalized and delivered to intracellular vesicles containing cathepsin proteases and the viral receptor Niemann-Pick C1. Previous studies have shown that EBOV triggers macropinocytosis of the viral particles in a glycoprotein (GP)-dependent manner, but the molecular events required for filovirus internalization remain mostly unknown. Here we report that the diacylglycerol kina...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
(PLOS) Vaccines that induce protective T-cell responses could protect against members across the filovirus family, according to a study published Feb. 28 in the open-access journal PLOS Pathogens by Tom á š Hanke of the University of Oxford, Bette Korber of the Los Alamos National Laboratory, and colleagues
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The family of viruses known as the Filoviridae (filo, from the Latin for thread) is well known for the ebolaviruses, which cause the hemorrhagic disease that regularly erupts in Africa. As Earth’s virome is slowly revealed, other filoviruses are discovered. The first filovirus discovered was Marburg virus, first described in 1967 in Germany when grieve […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information ebolavirus filovirus hemorrhagic fever Mengla virus minigenote spillover viral viruses Source Type: blogs
Uganda is one of the few countries in Africa that has been experiencing outbreaks of viral hemorrhagic fevers such as Ebola, Marburg and Crimean-Congo Hemorrhagic fevers. In 2017 Uganda experienced a Marburg V...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Andrea Marzi, Andrea R. Menicucci, Flora Engelmann, Julie Callison, Eva J. Horne, Friederike Feldmann, Allen Jankeel, Heinz Feldmann, Ilhem Messaoudi
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
A man walks down the street. It's a street in a strange world. Maybe it's the Third World. Maybe it's his first time around. He doesn't speak the language. He holds no currency. He is a foreign man. He is surrounded by the sound. The sound! Cattle in the marketplace, scatterlings and orphanages. He looks around, around.By Jan LundiusSTOCKHOLM / ROME, Jan 21 2019 (IPS)I thought about this song by Paul Simon while I in 2011 spent a few weeks in Kinshasa. I was a foreign man in a strange world, surrounded by sights and sounds, completely dependent on my new-found Congolese friends. When our taxi got stuck in a traffic jam and...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Aid Armed Conflicts Crime & Justice Featured Headlines Health Human Rights TerraViva United Nations Source Type: news
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