How Genomic Research is Changing Heart Care
Genomic testing is most frequently associated with cancer testing, but this area of research is beginning to make an impact on cardiovascular care. A recent scientific statement by the American Heart Association shined a spotlight on how the expressed genome can potentially be used to diagnose diseases and predict who will develop diseases such as coronary artery disease (CAD), stroke, heart failure, and arrhythmias. According to the statement, scientists now have the ability to address disease at many levels that were inaccessible during the past century. This includes the genome, transcriptome, epigenome, proteome, metabolome, cells, tissues, and organs. The authors said each of the omics approaches is still a work in progress, and many of the initial findings have not yet been validated via the systematic replication in independent studies. "Nonetheless, we can expect the next five to 10 years to witness enormous progress in the application of the approaches to the study of specific cardiovascular diseases in patients," the authors wrote. "A critical step to facilitate the eventual widespread use of the expressed genome in the clinic is the funding of large-scale efforts to validate, replicate, and integrate the information streams arising from various omics studies such as the National Heart, Lung, and Blood Institute's (NHLBI) Trans-Omics for Precision Medicine Program." As that happens, the authors added, a host of new disease biomarkers should ...
This study aimed to assess the effect of blood products on outcomes for LDLT recipients, focusing on apheresis platelets. Methods:: This retrospective study included 126 recipients who underwent their first adult-to-adult LDLT. Twenty-four variables including consumption of blood products of 126 LDLT recipients were assessed for their link to short-term outcomes and overall survival. Kaplan-Meier survival curve and the log-rank test were used for recipient survival analysis. A multivariate Cox proportional-hazard model and a propensity score analysis were applied to adjust confounders after potential risk factors were...
Abstract Background: Most studies on enhanced recovery after surgery (ERAS) for gastric cancer exclude patients who received neoadjuvant chemotherapy. Here, we aimed to evaluate whether patients who received neoadjuvant chemotherapy can be enrolled into the ERAS program for locally advanced gastric cancer. Methods: From April 2015 to July 2017, 114 patients who received neoadjuvant chemotherapy for locally advanced gastric cancer were randomized into ERAS and standard care (SC) groups. Postoperative length of stay, complications, bowel function, and nutritional status were recorded. Results:: The postope...
Conclusions: The analysis of different payment modes toward the medical economic characteristics based on Gamma model is basically rational. Medical payment modes are having certain influence toward the hospitalization expenses of cervical cancer patients in an extent, as drug costs, treatment costs, and examination costs appear to be the main causes. PMID: 29451142 [PubMed - in process]
Advance brings us closer to growing transplant organs inside animals or being able to genetically tailor compatible organs, say researchersGrowing human organs inside other animals has taken another step away from science-fiction, with researchers announcing they have grown sheep embryos containing human cells.Scientists say growing human organs inside animals could not only increase supply, but also offer the possibility of genetically tailoring the organs to be compatible with the immune system of the patient receiving them, by using the patient ’s own cells in the procedure, removing the possibility of rejection.Continue reading...
https://www.usnews.com/news/best-states/missouri/articles/2018-02-16/doctor-said-it-was-cancer-it-wasnt-but-news-came-too-late Interesting article.
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This study assessed and compared the resource requirement of 3 adaptive strategies.
International brachytherapy consortiums are advocating for the incorporation of magnetic resonance imaging (MRI) into the cervical brachytherapy process as a standard-of-care. Although some evaluations have been performed to quantify the effect on procedural time, little is known about the views and experiences of key stakeholders during the transition from CT to MR-guided brachytherapy. This qualitative research project explored insights from key stakeholders related to a change in the gynaecological brachytherapy process.
Radiation review is a weekly clinic in the radiotherapy treatment (RT) care trajectory. It is an opportunity for patients undergoing RT to discuss emergent health issues with their care team. Recently, there was an opportunity to leverage technology to improve the arrival process of patients to this clinic and communication amongst the care team.
Healthcare leaders are brought together into teams to accomplish complex tasks, ranging from clinical operations to strategic planning. Frequently, little consideration is given to the team members' different strengths and styles, or how those differences may impact on the effectiveness of the leadership team. The purpose of this initiative was to improve the effectiveness of a Radiation Therapy (RT) Leadership Team at a large, academic cancer centre using evidence-based team strengthening techniques.
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