How Genomic Research is Changing Heart Care

Genomic testing is most frequently associated with cancer testing, but this area of research is beginning to make an impact on cardiovascular care. A recent scientific statement by the American Heart Association shined a spotlight on how the expressed genome can potentially be used to diagnose diseases and predict who will develop diseases such as coronary artery disease (CAD), stroke, heart failure, and arrhythmias. According to the statement, scientists now have the ability to address disease at many levels that were inaccessible during the past century. This includes the genome, transcriptome, epigenome, proteome, metabolome, cells, tissues, and organs. The authors said each of the omics approaches is still a work in progress, and many of the initial findings have not yet been validated via the systematic replication in independent studies. "Nonetheless, we can expect the next five to 10 years to witness enormous progress in the application of the approaches to the study of specific cardiovascular diseases in patients," the authors wrote. "A critical step to facilitate the eventual widespread use of the expressed genome in the clinic is the funding of large-scale efforts to validate, replicate, and integrate the information streams arising from various omics studies such as the National Heart, Lung, and Blood Institute's (NHLBI) Trans-Omics for Precision Medicine Program." As that happens, the authors added, a host of new disease biomarkers should ...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Cardiovascular Source Type: news

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Abstract Atrial fibrillation (AF) is the most widely recognized arrhythmia. Systemic arterial hypertension, diabetes, obesity, heart failure, and valvular heart diseases are major risk factors for the onset and progression of AF. Various studies have emphasized the augmented anxiety rate among AF patients due to the poor quality of life; however, little information is known about the possibility of triggering atrial fibrillation by anxiety. The present review sought to underline the possible pathophysiological association between AF and anxiety disorders and suggests that anxiety can be an independent risk factor ...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
[Abstract unavailable] Keywords: Human trafficking; Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
Conclusions: The findings suggest that the prevalence of pain acceptance is relatively low for Chinese cancer patients. The cancer pain acceptance is affected by age, gender, pain duration, number of pain sites, and duration of taking analgesics. The acceptance of cancer pain is negatively correlated with depression and anxiety. Therefore, patients with risk factors for low pain acceptance should receive more attention in Chinese medical settings. PMID: 30906486 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Conclusion: We conclude that BTVA may have a future role in the treatment of lung cancer and should be investigated further in clinical trials.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
The objective of this study was to evaluate whether concurrent thoracentesis and tissue biopsy is superior to sequential sampling. Methods: Retrospective chart review was performed for patients who had a pleural cytology from May 2014 until January 2017. Patients without parenchymal, pleural, or mediastinal abnormalities and those with a prior primary thoracic malignancy were excluded. Patients with an effusion and additional suspect findings were grouped based upon whether initial approach was concurrent versus sequential. The following outcomes were documented: lag time to diagnosis from thoracentesis, lag time to hem...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conclusion: Application of MMC is safe and is associated with a reduction in frequency of bronchoscopic balloon dilation in patients with post–lung transplant airway stenosis.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Since the development of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for lung cancer treatment, the need for a rebiopsy has increased. To select an appropriate therapeutic regimen, the genetic alterations in cancerous tissue should be determined. A rebiopsy plays an important role in the treatment of patients with diseases that are refractory to the previous generation of EGFR tyrosine kinase inhibitors. Cell-free DNA-based exploration is useful for determining the cause of treatment resistance in cases in which a rebiopsy is difficult; however, this method cannot detect histologic c...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Brief Reports Source Type: research
No abstract available
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Online Articles: Letters to the Editor Source Type: research
Authors: Leong P, Macdonald MI, Ko BS, Bardin PG Abstract Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist but combined disease is often not recognised. Since symptoms overlap significantly, it is common for patients' presentations to be attributed to one disease alone, and for the other to be overlooked. The effect of COPD and CVD goes beyond the shared risk factors of smoking and advancing age. The presence of COPD adversely affects cardiac disease and vice versa. In comparison to individuals with one disease alone, those with both conditions have a higher mortality...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Authors: Chow CK, Timmis A PMID: 30906998 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
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