Discovery of a potential therapeutic target to combat trypanosomes

(CNRS) Using cryo-electron microscopy, French researchers at the Institut de Biologie Mol é culaire et Cellulaire (CNRS/Universit é de Strasbourg) have analyzed the structure of trypanosomes parasites in details and revealed one of their potential weak points, which has remained undetected until now. This discovery opens the path to the development of new safer therapies that are less toxic and more specific against trypanosomes, the parasites causing the Chagas disease and the African sleeping sickness.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Abstract Elimination programs targeting TriTryp diseases (Leishmaniasis, Chagas' disease, human African trypanosomiasis) significantly reduced the number of cases. Continued surveillance is crucial to sustain this progress, but parasite molecular surveillance by genotyping is currently lacking. We explain here which epidemiological questions of public health and clinical relevance could be answered by means of molecular surveillance. Whole-genome sequencing (WGS) for molecular surveillance will be an important added value, where we advocate that preference should be given to direct sequencing of the parasite's gen...
Source: Trends in Parasitology - Category: Parasitology Authors: Tags: Trends Parasitol Source Type: research
Conclusion: This study is one of the first studies related to the production of Trypanosoma species in Turkey and planned to provide a basis for the studies of African sleeping disease, Chagas disease and their agents. PMID: 32212582 [PubMed - as supplied by publisher]
Source: Turkish Society for Parasitology - Category: Parasitology Authors: Tags: Turkiye Parazitol Derg Source Type: research
(Clemson University) In the quest to develop more effective treatments for parasitic diseases, scientists look for weaknesses in the organisms' molecular machinery. A team of College of Science researchers at Clemson recently contributed to that understanding by discovering the function of a specific protein in the three related parasites that cause African sleeping sickness, Chagas disease and Leishmaniasis -- diseases that are sometimes fatal and afflict millions worldwide.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scienti...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
The objective is to use in-silico screening of known antiparasitic germacranolides against recognized protozoal protein targets in order to provide insight into the molecular mechanisms of activity of these natural products. METHODS: Conformational analyses of the germacranolides were carried out using density functional theory, followed by molecular docking. A total of 88 Leishmania protein structures, 86 T. brucei protein structures, and 50 T. cruzi protein structures were screened against 27 antiparasitic germacranolides. RESULTS: The in-silico screening has revealed which of the protein targets of Leishmania ...
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research
Trypanosoma is a genus of single-cell eukaryote organisms—parasites living in the bloodstream (or sometimes inside cells) of humans or other mammals and causing a number of serious diseases (such as Leishmaniasis, African trypanosomiasis [sleeping sickness], American trypanosomiasis [Chagas disease], and others). In most cases, they are transmitted by blood-feeding invertebrates,...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Commentaries Source Type: research
Wow - we received so many excellent comments on how parasites and the number 5 go together! Here are many of them - in no particular order - for your viewing pleasure:Pentatrichomonas hominis is a nonpathogenic intestinal flagellate named for its 5 flagella (penta from the Greek pente, meaning five + trich, pertaining to hair [flagella]). By Neil Anderson and Bernardino Rocha.There are 5 lobes of the lung, and all can be infected by Paragonimusspecies. By Brian Duresko.The are 5Plasmodiumspecies that are responsible for the bulk of malaria in humans:P. falciparum, P. vivax, P. ovale, P. malariae, andP. knowlesi(t...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Publication date: Available online 29 July 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Vishal C. Kalel, Mengqiao Li, Stefan Gaussmann, Florent Delhommel, Ann-Britt Schäfer, Bettina Tippler, Martin Jung, Renate Maier, Silke Oeljeklaus, Wolfgang Schliebs, Bettina Warscheid, Michael Sattler, Ralf ErdmannAbstractTrypanosomatid parasites cause devastating African sleeping sickness, Chagas disease, and Leishmaniasis that affect about 18 million people worldwide. Recently, we showed that the biogenesis of glycosomes could be the “Achilles' heel” of trypanosomatids suitable ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Abstract More than 10 million people around the world are afflicted by Neglected Tropical Diseases, such as Chagas Disease, Human African trypanosomiasis, and Leishmania. These diseases mostly occur in undeveloped countries that suffer from a lack of economic incentive, research, and policy for new compound development. Sulfonamide moieties are effective scaffolds present in several compounds that are determinants to treat various diseases, principally neglected tropical diseases This review article examines the contribution of these scaffolds in medicinal chemistry in the last five years, focusing on three trypan...
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research
Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT01317B, PaperEsteban Rodriguez Arce, Eugenia Putzu, Michel Lapier, Juan Diego Maya, Claudio Olea-Azar, Gustavo Etcheverria, Oscar E. Piro, Andrea Medeiros, Florencia Sardi, Marcelo Comini, Gast ón Risi, Gustavo Salinas, Isabel Correia, João Pessoa, Lucía Otero, Dinorah Gambino In the search for a more effective chemotherapy for the treatment of Chagas disease and Human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
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