Autoimmunity against a glycolytic enzyme as a possible cause for persistent symptoms in Lyme disease

We present the case of a patient with evidence of exposure to Borrelia burgdorferi sl and a long history of debilitating fatigue, cognitive abnormalities and autonomic nervous system issues.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research

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It’s finally getting warm here in New England, and most of us have plans to enjoy the beautiful weather. And that’s why the Centers for Disease Control and Prevention (CDC) recently released a report raising awareness about how to prevent the tickborne infections that typically occur during this time of the year. Lyme disease is probably the most well-known, and the one for which diagnosis and treatment are most controversial. What is Lyme disease? Several countries around the world, especially in the Northern Hemisphere, and all 50 states in the US have already reported cases of Lyme. The disease is caused by ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
CONCLUSION: Improving the diagnosis and therapeutic management of patients believing themselves to be affected by chronic Lyme disease appears highly necessary both to limit their search for diagnosis and their experience of pain. It could be based on existing guidelines concerning medically unexplained symptoms to which the chronic Lyme disease issue appears quite similar on several points. PMID: 29706237 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Publication date: Available online 15 June 2017 Source:Microbes and Infection Author(s): Jorge Cervantes Lyme disease is a zoonosis caused by infection with Borrelia burgdorferi (Bb). A great amount of research has attempted to elucidate the mechanisms by which Bb causes inflammation and chronic symptomatology in some patients. Patients often seek unconventional treatments that lack scientific evidence, as medical care is unable to effectively explain and treat their illness. Bb-DNA can persist for long periods of time in some individuals, even after antibiotic therapy. Herein, scientific rationale is presented for a new ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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Source: Science - The Huffington Post - Category: Science Source Type: news
This morning, I awoke to find that I had been copied on dozens of Twitter message exchanges among several people who were discussing the pathology of Borrelia burgdorferi, the bacterium that causes Lyme disease, among human beings and mice. My first thought was "Seriously?! It's too early for this!" My second thought was "well, David, your Twitter sure has evolved from your pre-Lyme days when you used it mostly to promote vapid celebrity interviews." As I began my morning caffeine ritual and read through each of the messages, I gained a new appreciation for some of the real complexities of "in...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This study evaluated antibiotic vs placebo. The study was terminated early due to the determined likelihood that a beneficial effect would not be found. When this was critically analyzed with biostatistical methods, an article was published which I believe demonstrates that Klempner's study was so poorly designed and analyzed that in order for a treatment effect to have been observed, the antibiotic treated patients would have had to improve to a level of health which was a full standard deviation better than the average health of the general population. It's a reasonable hope for antibiotics to return a patient to a somew...
Source: Science - The Huffington Post - Category: Science Source Type: news
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
CONCLUSIONS: The reported incidence of LD in Poland, in our opinion, may be biased by overreporting and overdiagnosis. Nonspecific musculoskeletal and joint pain are the most frequent cause of LD suspicion and hospitalization. There is a necessity of better tests for active LD confirmation (especially in patients with musculoskeletal pain) as seroprevalence of anti Borrelia burgdorferi antibodies is high in endemic regions. PMID: 26641887 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
Conclusions The reported incidence of LD in Poland, in our opinion, may be biased by overreporting and overdiagnosis. Nonspecific musculoskeletal and joint pain are the most frequent cause of LD suspicion and hospitalization. There is a necessity of better tests for active LD confirmation (especially in patients with musculoskeletal pain) as seroprevalence of anti Borrelia burgdorferi antibodies is high in endemic regions.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
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