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Phase 1/2 study of the WT1 peptide cancer vaccine WT4869 in patients with myelodysplastic syndrome

WT4869 is a synthetic peptide vaccine derived from the Wilms’ tumor gene 1 (WT1) protein. This phase 1/2 open‐label study evaluated the safety and efficacy of WT4869, and biomarkers for response, in patients with myelodysplastic syndrome. WT4869 (5–1200 μg/dose) was administered intradermally every 2 weeks, according to a 3 + 3 dose‐escalation method in higher‐risk (International Prognostic Scoring System score ≥1.5) or lower‐risk (score
Source: Cancer Science - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research

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Abstract WT4869 is a synthetic peptide vaccine derived from the Wilms’ tumor gene 1 (WT1) protein. This phase 1/2 open‐label study evaluated the safety and efficacy of WT4869, and biomarkers for response, in patients with myelodysplastic syndrome. WT4869 (5–1200 μg/dose) was administered intradermally every 2 weeks, according to a 3+3 dose‐escalation method in higher‐risk (International Prognostic Scoring System score ≥1.5) or lower‐risk (score
Source: Cancer Science - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
Background: Myelodysplastic Syndrome (MDS) is a disorder of the bone marrow wherein hematopoietic cells fail to develop and differentiate into their mature forms. High iron stores in the body are known to have a detrimental effect on the overall outcome for the patient, however its exact role in the disease spectrum is currently unknown. We sought out to elucidate the role of Serum Ferritin against two end points - infection and death.Methods: The patient data was queried from METEOR (Methodist Environment for Translational Enhancement and Outcomes Research), a clinical data warehouse and analytics environment. We obtained...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Clinical Research (Excluding Clinical Trials) Source Type: research
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