Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

Conclusion: We demonstrate a novel mechanism how bacterial toxins activate the inflammasome and mediate the formation and release of cytokines:S. aureusα-toxin triggers an activation of the acid sphingomyelinase and a release of ceramides resulting in the release of lysosomal cathepsin B and formation of pro-inflammatory cytokines.Cell Physiol Biochem 2017;43:2170 –2184
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research

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Publication date: Available online 20 February 2020Source: The Lancet Global HealthAuthor(s): Xin Wang, You Li, Katherine L O'Brien, Shabir A Madhi, Marc-Alain Widdowson, Peter Byass, Saad B Omer, Qalab Abbas, Asad Ali, Alberta Amu, Eduardo Azziz-Baumgartner, Quique Bassat, W Abdullah Brooks, Sandra S Chaves, Alexandria Chung, Cheryl Cohen, Marcela Echavarria, Rodrigo A Fasce, Angela Gentile, Aubree GordonSummaryBackgroundSeasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-viru...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
We report a case of successful treatment of relapsed prosthetic valve Enterococcus faecalis endocarditis with oral amoxicillin/clavulanate. Enterococcal endocarditis is associated with a high relapse rate, even with the recommended treatment duration by the guidelines. Oral therapy is increasingly considered as part of the management of such serious infections.Graphical abstract
Source: IDCases - Category: Infectious Diseases Source Type: research
Condition:   Novel Coronavirus Pneumonia Intervention:   Biological: NK Cells Sponsors:   Xinxiang medical university;   First Affiliated Hospital of Xinjiang Medical University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Nosocomial Pneumonia Intervention:   Diagnostic Test: Microbiological diagnostics on pulmonary secretion Sponsors:   Zealand University Hospital;   Slagelse Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Pulmonary Fibrosis Due to 2019-nCoV Interventions:   Drug: N-acetylcysteine+ Fuzheng Huayu Tablet;   Drug: N-acetylcysteine+Placebo Sponsors:   ShuGuang Hospital;   Hubei Hospital of Traditional Chinese Medicine;   Jingmen No.1 People’s Hospital;   Tongji Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Substantial variation in antibiotic prescribing patterns related to CEWIs warrants development of combat-related clinical practice guidelines beyond infection prevention, to include strategies to reduce the use of unnecessary antibiotics and improve stewardship. PMID: 32074316 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Publication date: November 2019Source: Revista Portuguesa de Cardiologia (English Edition), Volume 38, Issue 11Author(s): Marta Braga, Helena Nascimento, Carla Sousa, Paula Dias, Maria Júlia Maciel, Filipe Macedo
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 21 February 2020Source: American Heart JournalAuthor(s):
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Boot W, Vogely HC, Jiao C, Nikkels PG, Pouran B, van Rijen MH, Ekkelenkamp MB, Hänsch GM, Dhert WJ, Gawlitta D Abstract Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operative infections in patients receiving orthopaedic implants. No comparable method is available for uncemented implants. Therefore, a hydrogel consisting of hyaluronic and polylactic acids was evaluated in a rabbit model for delivery of antimicrobial agents to prevent post-operative infections. In a pilot study, the suitability of the in vivo model was assessed by testing the hydrogel as ca...
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research
Publication date: Available online 20 February 2020Source: Materials Today: ProceedingsAuthor(s): Asha Gangadharan, Jismy Jolly, Nayomi JohnAbstractBioprospecting is the searching of novel bioactive natural products from unexplored natural environment. The aim of the study was to isolate novel therapeutic agents from marine bacterium. The marine bacterium was identified as Serratia marcescens using molecular identification methods. The secondary metabolites were extracted and showed single spot on TLC at Rf of 0.74. The metabolite showed good antioxidant and antibacterial activity against Staphylococcus aureus, pseudomonas...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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