< b > < i > Staphylococcus aureus < /i > < /b > α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

Conclusion: We demonstrate a novel mechanism how bacterial toxins activate the inflammasome and mediate the formation and release of cytokines:S. aureusα-toxin triggers an activation of the acid sphingomyelinase and a release of ceramides resulting in the release of lysosomal cathepsin B and formation of pro-inflammatory cytokines.Cell Physiol Biochem 2017;43:2170 –2184
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research