Proton therapy for prostate cancer is advantageous to imrt according to new study
(Northwestern Memorial HealthCare) Proton therapy treatment for prostate cancer is associated with higher survival rates and decreased risk of complications compared to intensity-modulated radiation therapy (IMRT) according to a new study by researchers at the Northwestern Medicine Chicago Proton Center.
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Yu-Peng Wu, Zhi-Bin Ke, Fei Lin, Yao-An Wen, Sheng Chen, Xiao-Dong Li, Shao-Hao Chen, Xiong-Lin Sun, Jin-Bei Huang, Qing-Shui Zheng, Xue-Yi Xue, Yong Wei, Ning Xu
Could the administration of an yttrium-90-based radionuclide improve the performance...Read more on AuntMinnie.comRelated Reading: New PET/CT tracer reliably detects prostate cancer SABR slows prostate cancer progression PSMA-PET/CT again shows prowess for prostate cancer Choline-PET boosts mpMRI for prostate cancer detection
In this study, we evaluated FASN expression at both mRNA and protein levels and assessed the association between FASN expression and prognosis in male Han Chinese with PCa treated with radical prostatectomy (RP). Methods: Expression profile and prognostic value of FASN were analyzed in tissue microarray (TMA) and data retrieved from databases including TCGA public database, GEO database, and our sequencing data with whole clinicopathological characteristics. Results: FASN expression was associated with clinical parameters and biochemical recurrence of prostate cancer. The relative expression of FASN mRNA was higher...
Frequencies of genomic alterations in current therapeutic targets similar for AFR, EUR men
We examined the underlying mechanisms using cell lines and tumour tissue samples. IGF-I had differential effects on the process of EMT: inhibiting in normal and promoting in cancer cells, whereas hyperglycamia alone had a stimulatory effect in both. These effects were independent of IGF and in both cases, hyperglycaemia induced an increase IGFBP-2(tumour promoter) and FOXA1. A positive correlation existed between levels of IGFBP-2 and FOXA1 in benign and cancerous prostate tissue samples and in vitro and in vivo data indicated that FOXA1 strongly interacted with the IGFBP-2 gene in normal prostate epithelial cells that was...
TUESDAY, July 14, 2020 -- African-American (AFR) men with prostate cancer have distinct genomic alterations from European-American (EUR) men, according to a study published online July 10 in Clinical Cancer Research. Yusuke Koga, from the Boston...
(Baylor College of Medicine) Researchers at Baylor College of Medicine reveal for the first time the complete 3-D structure of the active, full-length androgen receptor-coactivator complex as it interacts with DNA.
Prostate cancer has been convincingly linked to the sexually transmitted human papillomavirus (HPV) for the first time.
It is hypothesised that high risk for cancer human papillomaviruses (HPVs) have a causal role in prostate cancer.
Just over 20 percent of men with prostate cancer tested positive for the human papilloma viruses, or HPV. The researchers suggest the virus might cause the cancer in some men.