Choriocapillaris signal voids in maternally inherited diabetes and deafness and in pseudoxanthoma elasticum
Purpose:To evaluate the pattern of choriocapillaris signal voids in maternally inherited diabetes and deafness and in pseudoxanthoma elasticum in eyes before the development of any geographic atrophy. Methods:The choriocapillaris under the central macula was imaged with the Optovue RTVue XR Avanti using a 10 μm slab thickness. Automatic local thresholding of the resultant raw data extracted areas of absent flow signal, called signal voids, and these were counted and logarithmically binned. The signal void patterns were analyzed in four eyes of two patients with maternally inherited diabetes and deafness and four eyes of three patients with pseudoxanthoma elasticum. None of the patients had geographic atrophy. These data were compared with 55 eyes of 38 healthy control subjects and analyzed with generalized estimating equations. Results:The choriocapillaris images in maternally inherited diabetes and deafness and pseudoxanthoma elasticum show that the model of signal voids followed a power law distribution, but with a slope and offset much lower than the normal control group, adjusted for age (P
Decreased skeletal muscle strength and mitochondrial dysfunction are characteristic of diabetes. The actions of insulin and IGF-1 through the insulin receptor (IR) and IGF-1 receptor (IGF1R) maintain muscle mass via suppression of forkhead box O (FoxO) transcription factors, but whether FoxO activation coordinates atrophy in concert with mitochondrial dysfunction is unknown. We show that mitochondrial respiration and complex I activity were decreased in streptozotocin (STZ) diabetic muscle, but these defects were reversed in muscle-specific FoxO1, -3, and -4 triple-KO (M-FoxO TKO) mice rendered diabetic with STZ. In the ab...
ConclusionsPatients with NFAI and 1-mg ODST ≤ 1.8 μg/dl presented higher odds of T2DM and higher levels of FBG and HOMA index than healthy controls.
ConclusionsThis study shows that vitamin D3 content is associated with the incidence of diabetes in people with high level of uric acid. This study offers a fresh perspective on the elements that influence the etiology of diabetes in hyperuricemia patients.
ConclusionsWomen with TSH levels>4.0 mIU/L have an increased odds of GDM regardless of TA status but at TSH levels
In her first major role in a feature film, she wasn ’t fazed by things that might unnerve others, but she had to show filmmakers how to work with deafness.
"In 2020, 57% of all US households purchased plant-based foods (that's over 71 million households), up from 53% in 2019," the association says.WebMD Health News
Despite the high burden of cardiometabolic disease worldwide, there continues to be fragmented care and lack of ideal coordination at the public health level. The World Health Organization and World Heart Federation are making strides to address this and pave the way forward.ACC.org
Presentation Description: Diabetic retinopathy is the leading cause of blindness in working age adults in the United States. It is challenging to address in both rural and urban underserved settings, which suffer from shortages of eye specialists. This talk will describe the approach taken to address this condition in a medically underserved area (South Los Angeles) by researchers in the Center for Biomedical Informatics at Charles R. Drew University of Medicine and Science, using telehealth and machine learning on data from patient electronic health records. Speaker Bio: Omolola Ogunyemi, PhD, FACMI is the Director of ...
Adults aged 18-24 gained the most weight over 10 years compared with older individuals and should be a key target for prevention programs, say researchers.Medscape Medical News