High Uric Acid-Induced Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via the TLR4/NF-kB Signaling Pathway

Conclusions: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF- κB signaling pathway, and the targeted intervention of the TLR4/NF-κB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT.Am J Nephrol 2017;46:333 –342
Source: American Journal of Nephrology - Category: Neurology Source Type: research