A Retrospective Analysis of & #x03B3; δ T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps

Background/Aims: To examine whether #x03B3; δ T cell is expressed in the nasal mucosa of chronic rhinosinusitis (CRS) patients and its potential association with recurrence of nasal polyps.Methods: Thirty-six patients with CRS with nasal polyps (CRSwNP) and 25 patients with CRS without nasal polyps (CRSsNP) were recruited. Twenty-six patients with other nasal diseases served as controls. The CRSwNP group was divided into the eosinophilic CRSwNP and noneosinophilic CRSwNP groups. The expression of #x03B3; δ T cells was detected by immunohistochemistry. The expression of each subtype of #x03B3;δ T cells was detected by using qRT-PCR. All patients underwent nasal endoscopy, and postoperative follow-up lasted over 12 months. CRS patients were evaluated by preoperative VAS scores of symptoms and nasal endoscopy Lund-Kennedy scores.Results: The expression of #x03B3; δ T cells in the CRSwNP groups was stronger than in the CRSsNP and the control group (p

Source: ORL - October 25, 2017 Category: ENT & OMF Source Type: research