Pregnancy Complications and Wheezing and Asthma in Childhood.

Pregnancy Complications and Wheezing and Asthma in Childhood. Am J Respir Crit Care Med. 2017 Oct 24;: Authors: Rusconi F, Gagliardi L Abstract This review focuses on recent advances in the field of several frequent maternal complications in pregnancy and asthma and wheezing in childhood, for which large birth cohort studies have recently provided clues. Within the framework of epidemiologic studies, we discuss potential mechanisms, mediators and confounders involved in associations, in an attempt to discern causal pathways. Preeclampsia, a pregnancy-specific multiorgan disease that affects 2-4% of women in developed countries, is characterized by placental dysfunction and is associated with preterm delivery, fetal growth restriction and vascular and lung effects in the fetus. Recent cohort studies have found an association with asthma and wheezing in offspring, probably partly mediated by being preterm or small for gestational age. Obesity, diabetes, maternal depression, anxiety and psychological stress are increasingly complicating the course of pregnancy. With the exception of diabetes, for the other conditions, several studies have found associations especially with wheezing in early childhood. Biologically plausible mechanisms acting on the developing lung and on the modulation of immune function have been suggested. The importance of prenatal and postnatal confounders and mediators still needs to be fully ascertained. Cesarean deliveries are increa...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research

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Background: Many of those aging with HIV suffer from distal neuropathic pain (DNP) due to HIV-associated sensory neuropathy (HIV-SN). Prior studies have linked chronic pain conditions to a variant of the catechol-O-methyltransferase (COMT), Val158Met. This variant confers reduced enzymatic activity and results in higher synaptic dopamine levels. Here we examined the role of Val158Met as a predictor of DNP in HIV-SN. Methods: In 1044 HIV-infected individuals enrolled in CNS HIV Antiretroviral Therapy Effects Research, an observational study across six US institutions, we characterized the relationship between Val158Met...
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Conclusion: ART-naive Ethiopian HIV patients had a high prevalence of prediabetes and diabetes, with a poor agreement between HbA1c and OGTT. Diabetes was associated with inflammation, but not with adiposity and age. Diabetes was linked to insulin deficiency, rather than insulin resistance, which may represent a different entity than type 1 and 2 diabetes. This has implications for choice of drugs, when managing diabetes in African HIV patients.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Conclusion: Neuropsychiatric illness increased odds of being frail on a predominantly physical/motoric measure, but only when symptomatic. Lack of association with asymptomatic impairment may reflect the importance of functional limitation to frailty, or possibly a unique resilience phenotype. Understanding why sex and symptomatic neuropsychiatric illness are associated with frailty will be important in managing HIV-associated morbidity in aging populations.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Conclusion: Despite high ART coverage, good maternal health and very low vertical HIV transmission rate, maternal HIV infection remained associated with increased risk of adverse perinatal outcomes. Larger studies using first trimester ultrasound for pregnancy dating are needed to further assess associations with specific adverse perinatal outcomes.
Source: AIDS - Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
All about the Ambulatory Glucose Profile (AGP), that standardizes how blood sugar data is reported for doctors and patients dealing with diabetes.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
I joined a group from JDRF San Diego for a great group training ride this morning to finish off my third week of training for #ScottsDeathRide (100 miles in Death Valley this October with @erikdouds for JDRF – learn more and support us at https://diabadass.com/death-valley). I finished the week with 79.08 miles in the books (plus a handful of fun basketball sessions), and I’m feeling great!Coach Pat took us on a beautiful route that I really enjoyed! I’ll definitely ride some of those roads again to take in the views. (Stick around for a bonus clip at the end to watch my wife try to kill me with the garag...
Source: Scott's Diabetes Blog - Category: Endocrinology Authors: Tags: Biking Blog Posts JDRF Meet Ups Source Type: blogs
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Publication date: Available online 13 July 2019Source: Reproductive ToxicologyAuthor(s): Ana Cláudia Boareto, Caroline Gomes, Juliane Centeno Müller, Jonas Golart da Silva, Fernanda Vergara, Noruê Salum, Rafaela Maristany Sargaço, Rosângela Ribeiro de Carvalho, José Ederaldo Queiroz Telles, Cláudio Romero Farias Marinho, Francisco José Roma Paumgartten, Paulo Roberto DalsenterAbstractMalaria in pregnant women is associated with risk of maternal and perinatal morbidity and mortality, and there are few antimalarial drugs considered safe to treat them, so it is necessary to ...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Abstract This paper is a review of empirical studies, review and meta-analysis publications on yoga from the last few years. The review includes demographics/prevalence of yoga as a practice, bibliometric analyses of the yoga publications and the use of yoga for physical fitness and cognitive function. Most of the studies reviewed here involve yoga effects on psychiatric and medical conditions. These include pregnancy, prenatal and postpartum depression; stress, PTSD, anxiety, and obesity; cardiovascular conditions including hypertension; pain syndromes including arthritis, headaches and low back pain; autoimmune ...
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
This week’s Republican National Convention has resembled nothing so much as a circus sideshow. There was the norovirus outbreak among California staffers, a plagiarized speech delivered by the potential first lady of the United States, and even a moment when former Republican presidential candidate Ben Carson linked Hillary Clinton to Lucifer. As wacky as the RNC seems, it’s only the latest example of Republican leaders’ willingness to venture into the realm of the imagination. When it comes to nearly every aspect of health, for instance, from health care to women’s issues to vaccines to mental heal...
Source: Science - The Huffington Post - Category: Science Source Type: news
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