22.5 Animal Models and Amphetamine Isomers in Attention-Deficit/Hyperactivity Drug Development

Psychostimulants with different isomers of amphetamine, such as Adderall and d-amphetamine, are known to be safe and effective treatments for ADHD. Clinical studies have demonstrated that l-amphetamine is not an inactive isomer. Adderall contains approximately 25 percent l-amphetamine; Evekeo ® contains approximately 50 percent l-amphetamine. Clinical studies and animal models have suggested that there may be a role for different isomer combinations of amphetamine based on the patient’s diagnosis and genetic makeup.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research

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Publication date: Available online 12 November 2019Source: NeuroImageAuthor(s): Juha Salmi, Mostafa Metwaly, Jussi Tohka, Kimmo Alho, Sami Leppämäki, Pekka Tani, Anniina Koski, Tamara Vanderwal, Matti LaineAbstractIndividuals with attention-deficit/hyperactivity disorder (ADHD) have difficulties navigating dynamic everyday situations that contain multiple sensory inputs that need to either be attended to or ignored. As conventional experimental tasks lack this type of everyday complexity, we administered a film-based multi-talker condition with auditory distractors in the background. ADHD-related aberrant brain r...
Source: NeuroImage - Category: Neuroscience Source Type: research
CONCLUSION: This case report suggests that health and wellness coaching can be effective in supporting beneficial outcomes and can be useful in the multimodal management of ADHD. PMID: 31710834 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
The fate of a local company ’s treatment for attention deficit hyperactivity disorder is now in regulators’ hands. Supernus Pharmaceuticals Inc. (NASDAQ: SUPN) has submitted its application to the Food and Drug Administration to take its ADHD drug to market, the company announced Monday. If granted, that could mean gettin g the treatment to patients in the second half of 2020. Supernus has put the product candidate through a handful of phase 3 clinical trials, to study its ability to reduce ADHD…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Translational Psychiatry, Published online: 13 November 2019; doi:10.1038/s41398-019-0614-3Motor cortex facilitation: a marker of attention deficit hyperactivity disorder co-occurrence in autism spectrum disorder
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
In conclusion, our meta-analysis showed that there was no statistically significant difference in blood zinc and hair zinc levels between ADHD children and adolescents compared with healthy children and adolescents. PMID: 31704595 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Widening definitions of health conditions have the potential to affect millions of people and should only occur when there is strong evidence of benefit. In the last version of the Diagnostic and Statistical M...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Research article Source Type: research
Journal of Child and Adolescent Psychopharmacology, Ahead of Print.
Source: Journal of Child and Adolescent Psychopharmacology - Category: Pediatrics Authors: Source Type: research
Publication date: Available online 10 November 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Alessio Bellato, Iti Arora, Chris Hollis, Madeleine J. GroomAbstractAlthough arousal mechanisms have frequently been found to be atypical in ADHD, these findings usually emerged from indirect behavioural measures which give only a limited understanding of arousal dysregulation in this condition. To assess the hypothesis that functioning of the autonomic nervous system (ANS), one component of arousal, is atypical in ADHD, we carried out a systematic review of the literature on 55 studies investigating electro-dermal,...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Attention-Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity and impulsivity. In childhood ADHD has an estimated prevalence rate of 5 –7% (American Psychiatric Association, 2013; Polanczyk, de Lima, Horta, Biederman,&Rohde, 2007; Thomas, Sanders, Doust, Beller,&Glasziou, 2015; Willcutt, 2012); during the transition to adolescence a significant reduction of clinical manifestations is usually observed. Males are more often involved, with a gender ratio of 2:1 in clinical samples and 4:1 in population samples (American Psychiatric Association, 2013;...
Source: Archives of Psychiatric Nursing - Category: Nursing Authors: Source Type: research
In this study, we proposed a dynamical systems perspective to assess how the DMN over time recruits different configurations of network segregation and integration. Specifically, we were interested in configurations for which both intra- and inter-network connections are retained, as opposed to commonly used methods which assess network segregation as a single measure. From resting-state fMRI data, we extracted three different stable configurations of FC patterns for the DMN, namely synergies. We provided evidence supporting our hypothesis that ADHD differs compared to controls, both in terms of recruitment rate and topolo...
Source: NeuroImage - Category: Neuroscience Source Type: research
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