22.5 Animal Models and Amphetamine Isomers in Attention-Deficit/Hyperactivity Drug Development

Psychostimulants with different isomers of amphetamine, such as Adderall and d-amphetamine, are known to be safe and effective treatments for ADHD. Clinical studies have demonstrated that l-amphetamine is not an inactive isomer. Adderall contains approximately 25 percent l-amphetamine; Evekeo ® contains approximately 50 percent l-amphetamine. Clinical studies and animal models have suggested that there may be a role for different isomer combinations of amphetamine based on the patient’s diagnosis and genetic makeup.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research