RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2 -deficient mice, a model for Rett syndrome

ConclusionsThis comparative omics analysis supports previous works indicating widespread CNS dysfunction and may serve as a valuable resource for those interested in cellular dysfunction in RTT.
Source: Molecular Autism - Category: Molecular Biology Source Type: research

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The objective of this article is to review the literature for safety and efficacy of commonly prescribed antihypertensive agents in pediatrics. Thus far, the most data to support use in children was found for angiotensin-converting enzyme inhibitors (ACE-I), angiotensin receptor blockers (A RB), and calcium channel blockers (CCB). Several gaps were noted in the literature, particularly for beta blockers, vasodilators, and the long-term safety profile of antihypertensive agents in children. Further clinical trials are needed to guide safe and effective prescribing in the pediatric popul ation.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Publication date: 1 January 2021Source: Personality and Individual Differences, Volume 168Author(s): Jenna H. Beffel, Kyla M. Cary, Amy K. Nuttall, William J. Chopik, Megan K. Maas
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Coyne Enteroviruses manipulate host membranes to form replication organelles, which concentrate viral and host factors to allow for efficient replication. However, this process has not been well-studied in living cells throughout the course of infection. To define the dynamic process of enterovirus membrane remodeling of major secretory pathway organelles, we have developed plasmid-based reporter systems that utilize viral protease-dependent release of a nuclear-localized fluorescent protein from the endoplasmic reticulum (ER) membrane during infection, while retaining organelle-specific fluorescent protein markers suc...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: January 2021Source: Materials Science and Engineering: C, Volume 118Author(s): Da-Wang Zhao, Kang-Qing Zuo, Kai Wang, Zhao-Yang Sun, Yu-Peng Lu, Lei Cheng, Gui-Yong Xiao, Chao Liu
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 23 September 2020Source: Materials LettersAuthor(s): Liu Yan, Hu Qing, Zhang Kun, Yang Fuwei, Yang Lu, Wang Liqin
Source: Materials Letters - Category: Materials Science Source Type: research
HIGH cholesterol doesn't usually produce any symptoms but it does pave the way for heart disease. Simple dietary tweaks can lower your cholesterol, including eating daily servings of a particular snack.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
After significant APA advocacy, the House Veterans ’ Affairs Committee removed a proposal to implement a pilot program allowing clinical psychologists to prescribe and manage medications for veterans who seek care in the Veterans Health Administration.After learning about the proposal, APA issued an advocacy alert that resulted in over 1,000 members sending more than 3,000 letters to their elected officials on Capitol Hill, opposing the proposal and urging lawmakers to ensure veterans receive the highest quality mental health care possible. Similarly, APA leadership, as well as government relations and policy staff m...
Source: Psychiatr News - Category: Psychiatry Tags: advocacy APA lobbying psychologists prescribing Saul Levin VA veterans Source Type: research
Conclusions: There is an abundance of the academic literature and media reports on the potential of drugs that could attenuate or exacerbate COVID-19 disease. This is leading to trials of repurposed drugs and uncertainty among patients and clinicians concerning continuation or cessation of prescribed medications. Our review indicates that the impact of currently prescribed drugs on ACE2 has been poorly studied in vivo, particularly in human lungs where the SARS-CoV-2 virus appears to enact its pathogenic effects. We found no convincing evidence to justify starting or stopping currently prescribed drugs to influence outcome...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ03538F, PaperJunfeng Shi, Hong Zhang, Yue Yu, Ming Yan, Lingwei Liu, Haotong Zhu, Yongming Ye, Yunhe Zhao, Ying Xia, Jing Guo In this experiment, Calcium alginate (CA)/polyethylene glycol diacrylate (PEGDA)/polyvinyl alcohol(PVA) composite fiber containing PVA microcrystalline cross-linking point and PEGDA/CA double network structure was prepared by "one pot method", freeze-thaw cycle... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
“Lifestyle medicine is only for rich people, right?” a colleague asked me several years ago, questioning my involvement in this relatively new field of medicine that guides people toward healthy habits. This has been a common misperception, for sure. But across the US, a revitalized brand of health activism is intent on bringing lifestyle medicine to a broader range of people. This is backed by a new effort from the American College of Lifestyle Medicine to engage communities most affected by chronic disease. The first pillar of healthy lifestyle: Food is medicine Lifestyle medicine is an evidence-based practic...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Food as medicine Health Health care disparities Healthy Eating Source Type: blogs
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