RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2 -deficient mice, a model for Rett syndrome

ConclusionsThis comparative omics analysis supports previous works indicating widespread CNS dysfunction and may serve as a valuable resource for those interested in cellular dysfunction in RTT.
Source: Molecular Autism - Category: Molecular Biology Source Type: research

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social behaviors and communication. In rodents and humans, prenatal exposure to antiepileptic valproic acid is associated with an increased risk for autistic-like characteristics. One potential treatment is oxytocin, a prosocial neuropeptide that can be delivered intranasally. However, the sex-specific effects of valproic acid exposure and intranasal oxytocin treatment on behavior have not been fully explored. Pregnant Long Evans rats were administered valproic acid (500 mg/kg) or saline midday on gestational day 12, ...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Research Reports Source Type: research
Novel sensor could one day detect electrical activity deep in living brains
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
This study investigated the relationship between serum calcium and clinical outcomes in patients with COVID-19.MethodThis study is a systematic review and meta-analysis by searching PubMed, Scopus, web of sciences until August 2021 using the keywords COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID, coronavirus disease, SARS-COV-infection. 2, SARS-COV-2, COVID19, calcium, calcium isotopes, calcium radioisotopes, hypercalcemia, and hypocalcemia were performed. Heterogeneity of studies was investigated usingI2 index, data were analyzed using meta-analysis (random effects model) with Comprehensive...
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractSummaryVitamin D intake over the recommended dose is usually associated with high serum 25(OH)D levels and generally not associated with symptoms of hypercalcemia. High doses of cholecalciferol need to be avoided to protect against vitamin D toxicity and related complications. Strict adherence to the clinical guidelines for treating vitamin D deficiency can ensure safe and effective treatment.PurposeWe observed a tendency to use high doses of cholecalciferol for vitamin D deficiency treatment or vitamin D supplementation. We aimed to determine the biochemical characteristics of patients with high normal and elevate...
Source: Archives of Osteoporosis - Category: Orthopaedics Source Type: research
IJERPH, Vol. 18, Pages 9861: Quality of Life and Child’s Autism-Specific Difficulties among Malaysian Main Caregivers: A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18189861 Authors: Siti Fairus Asahar Khasnur Abd Malek Mohamad Rodi Isa Caring for children with autism spectrum disorder (ASD) negatively impacts quality of life (QoL). This cross-sectional study aimed to determine the factors associated with perceived QoL and how problematic a child’s autism-specific difficulties are among the main caregivers of children with ASD who attend...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In conclusion, patients undergoing statin treatment have a lower risk of developing RVO compared to patients not taking statins.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
To evaluate the association between statin use and the risk of developing rheumatoid arthritis (RA) in a large, US case-control study.
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
inardi Flavio Rizzolio Cancer is one of the major causes of death in developed countries and current therapies are based on surgery, chemotherapeutic agents, and radiation. To overcome side effects induced by chemo- and radiotherapy, in recent decades, targeted therapies have been proposed in second and even first lines. Targeted drugs act on the essential pathways involved in tumor induction, progression, and metastasis, basically all the hallmark of cancers. Among emerging pathways, the cholesterol metabolic pathway is a strong candidate for this purpose. Cancer cells have an accelerated metabolic rate and require ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Cancers, Vol. 13, Pages 4689: CYP3A Activity in End-of-Life Cancer Patients Measured by 4β-Hydroxycholesterol/cholesterol Ratio, in Men and Women Cancers doi: 10.3390/cancers13184689 Authors: Helena Bergström Maria Helde Frankling Caritha Klasson Anita Lövgren Sandblom Ulf Diczfalusy Linda Björkhem-Bergman More than 50% of all drugs are metabolized by the cytochrome P450 3A enzyme (CYP3A). The aim of this study was to investigate if the CYP3A activity, measured by the endogenous marker 4β-hydroxycholesterol/cholesterol ratio (4β-OHC/C), is changed during the last weeks and da...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
We aimed to determine the relationship between statin adherence measured directly, and by self-report measures and serum cholesterol levels.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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